Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011
Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011
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DOI：
10.1111/aos.12480
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发表时间：
2015-02-01
影响因子：
3.4
通讯作者：
Xu, Liang
中科院分区：
文献类型：
--
作者：
Jonas, Jost B.;Wang, Ning Li;Xu, Liang
目的：探讨估计的筛板压差（TLCPD）优于眼内压（IOP）与青光眼标志物的相关性。方法：2011年以人群为基础的北京眼科研究纳入3468例。脑脊液压（CSFP）计算公式为：CSFP [mmHg] = 0.44 ×体重指数[kg/m(2)] + 0.16 ×舒张压[mmHg] - 0.18 ×年龄[Years] - 1.91。TLCPD为io - csfp。结果：在非青光眼人群中，平均TLCPD为5.8 +/- 4.1 mmHg，平均估计CSFP为8.9 +/- 3.7 mmHg。青光眼组IOP高于非青光眼组（p = 0.008）， CSFP低于非青光眼组（p < 0.001）， TLCPD高于非青光眼组（p < 0.001）。TLCPD组间差异最大（2.1 mmHg），其次是CSFP （1.7 mmHg）和IOP （0.4 mmHg）。开角型青光眼（OAG）与TLCPD升高相关[p < 0.001；优势比（OR）： 1.14；95%可信区间（CI）： 1.08, 1.19]但与IOP无关（p = 0.22; OR: 0.96; 95% CI: 0.89, 1.03）。相比之下，在调整年龄和前房深度后，闭角型青光眼（ACG）与较高的IOP相关（p = 0.03; B: 0.14; OR: 1.15; 95% CI: 1.01, 1.30），但与TLCPD无关（p = 0.98）。经性别、年龄、居住地、视盘面积和屈光不正校正后，视网膜神经纤维层厚度与较低的TLCPD相关（p = 0.036），而与IOP无关（p = 0.96）。在调整性别、视盘面积和屈光不正后，神经视网膜面积和体积与较小的TLCPD相关（p = 0.002, p < 0.001），但与IOP无关（p = 0.43和p = 0.25，分别）。结论：在OAG中，而在ACG中，计算的TLCPD与IOP与青光眼的存在和青光眼视神经病变的数量有更好的关联。这支持了低cfp在OAG发病机制中的潜在作用。
Purpose: To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma.Methods: The population-based Beijing Eye Study 2011 included 3468 individuals. Cerebrospinal fluid pressure (CSFP) was calculated as CSFP [mmHg] = 0.44 x Body Mass Index [kg/m(2)] + 0.16 x Diastolic Blood Pressure [mmHg] - 0.18 x Age [Years] - 1.91. TLCPD was IOP-CSFP.Results: In the non-glaucomatous population, mean TLCPD was 5.8 +/- 4.1 mmHg and mean estimated CSFP was 8.9 +/- 3.7 mmHg. IOP was higher (p = 0.008), CSFP was lower (p < 0.001), and TLCPD was (p < 0.001) higher in the glaucoma group than in the non-glaucomatous group. The intergroup difference was highest for TLCPD (2.1 mmHg) followed by CSFP (1.7 mmHg) and IOP (0.4 mmHg). Open-angle glaucoma (OAG) was associated with higher TLCPD [p < 0.001; odds ratio (OR): 1.14; 95% confidence intervals (CI): 1.08, 1.19] but not with IOP (p = 0.22; OR: 0.96; 95% CI: 0.89, 1.03). In contrast, angle-closure glaucoma (ACG) was associated with higher IOP (p = 0.03; B: 0.14; OR: 1.15; 95% CI: 1.01, 1.30) but not with TLCPD (p = 0.98), after adjustment for age and anterior chamber depth. Retinal nerve fibre layer thickness was associated with lower TLCPD (p = 0.036) but not with IOP (p = 0.96), after adjusting for gender, age, region of habitation, optic disc area and refractive error. Neuroretinal area and volume were associated with smaller TLCPD (p = 0.002, and p < 0.001, respectively), after adjusting for gender, optic disc area and refractive error, but not with IOP (p = 0.43 and p = 0.25, resp.).Conclusions: In OAG, but not in ACG, calculated TLCPD versus IOP showed a better association with glaucoma presence and amount of glaucomatous optic neuropathy. It supports the notion of a potential role of low CSFP in the pathogenesis of OAG.