Reversibility of acute intermediate phase bilirubin encephalopathy
Reversibility of acute intermediate phase bilirubin encephalopathy
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DOI：
10.1111/j.1651-2227.2009.01409.x
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发表时间：
2009-10-01
期刊：
影响因子：
3.8
通讯作者：
Ebbesen, Finn
中科院分区：
文献类型：
--
作者：
Hansen, Thor Willy Ruud;Nietsch, Lutz;Ebbesen, Finn
目的：显示潜在的扭转急性中晚期胆红素脑病。方法：个案研究。结果：6个极端黄疸的婴儿有症状的中晚期急性胆红素脑病。这些婴儿受到了积极的治疗。两名患者的脑部磁共振成像显示苍白球信号增加。随访时，所有婴儿的神经功能均正常。结论：中晚期急性胆红素脑病有时可能是可逆的。这些病例提供了一个强有力的论据，支持对出现极端黄疸和神经系统症状的婴儿进行快速和积极的干预。
Aim:To show the potential for reversing acute intermediate to advanced phase bilirubin encephalopathy.Methods:Case studies.Results:Six extremely jaundiced infants had symptoms of intermediate to advanced phase acute bilirubin encephalopathy. The infants were treated aggressively. Two patients had brain magnetic resonance imaging showing increased signals in the globus pallidus. On follow-up, all infants are neurologically normal.Conclusions:Intermediate-to-advanced stage acute bilirubin encephalopathy may occasionally be reversible. These cases provide a strong argument in favour of rapid and aggressive intervention in infants presenting with extreme jaundice and neurological symptoms.