Low heat pain thresholds in migraineurs between attacks.
Low heat pain thresholds in migraineurs between attacks.
复制标题
DOI：
10.1177/0333102414550417
复制
发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Chong CD
中科院分区：
文献类型：
--
作者：
Schwedt TJ;Zuniga L;Chong CD
在发作之间，偏头痛与对感官刺激的高度敏感有关。这项研究的目的是调查偏头痛患者发作之间对疼痛的超敏反应。测量了112名偏头痛患者、偏头痛未发作48小时的患者和75名健康对照的皮肤热痛觉阈值。使用双尾t检验比较了偏头痛患者和对照组的头部和手臂的痛阈值。在偏头痛患者中，计算了热痛阈值与头痛频率、超敏症状严重程度和下一次头痛之间的时间间隔之间的相关性。偏头痛患者的痛阈值在头部(43.9C+/−3.2C比45.1°C+/−3.0C，p=0.015)和上臂(43.2C+/−3.4C比44.8C+/−3.3C，p<；0.001)较低。痛觉阈值与头痛频率或痛觉异常症状严重程度之间无显著相关性。对于41名已知下一次头痛时间的偏头痛患者，下一次头痛时间与头部(r=.352，p=.024)和手臂(r=.312，p=.047)的痛阈值呈正相关。这项研究提供的证据表明，偏头痛患者在偏头痛发作之间有较低的热痛阈值。这些较低的痛阈值背后的机制也可能使偏头痛患者易于发生下一次偏头痛发作，这一假说得到了疼痛阈值与下一次偏头痛发作时间之间的正相关发现的支持。
Between attacks, migraine is associated with hypersensitivities to sensory stimuli. The objective of this study was to investigate hypersensitivity to pain in migraineurs between attacks. Cutaneous heat pain thresholds were measured in 112 migraineurs, migraine free for ≥48 hours, and 75 healthy controls. Pain thresholds at the head and at the arm were compared between migraineurs and controls using two-tailed t-tests. Amongst migraineurs, correlations between heat pain thresholds and headache frequency, allodynia symptom severity, and time interval until next headache were calculated. Migraineurs had lower pain thresholds than controls at the head (43.9°C+/−3.2°C vs. 45.1°C+/−3.0°C, p=.015) and arm (43.2°C+/−3.4°C vs. 44.8°C+/−3.3°C, p<0.001). There were not significant correlations between pain thresholds and headache frequency or allodynia symptom severity. For the 41 migraineurs for whom time to next headache was known, there were positive correlations between time to next headache and pain thresholds at the head (r=.352, p=.024) and arm (r=.312, p=.047). This study provides evidence that migraineurs have low heat pain thresholds between migraine attacks. Mechanisms underlying these lower pain thresholds could also predispose the migraineur to their next migraine attack, a hypothesis supported by finding positive correlations between pain thresholds and time to next migraine attack.
登录
查看更多内容
影响因子：
5.3
作者：
Lee, Michael C.;Zambreanu, Laura;Tracey, Irene
通讯作者：
Tracey, Irene
影响因子：
5.1
作者：
Sand, T.;Zhitniy, N.;Stovner, L. J.
通讯作者：
Stovner, L. J.
影响因子：
4.9
作者：
LoPinto, C.;Young, W. B.;Ashkenazi, A.
通讯作者：
Ashkenazi, A.
影响因子：
11.2
作者：
Edelmayer, Rebecca M.;Vanderah, Todd W.;Majuta, Lisa;Zhang, En-Tan;Fioravanti, Beatriz;De Felice, Milena;Chichorro, Juliana G.;Ossipov, Michael H.;King, Tamara;Lai, Josephine;Kori, Shashi H.;Nelsen, Andrew C.;Cannon, Keri E.;Heinricher, Mary M.;Porreca, Frank
通讯作者：
Porreca, Frank
影响因子：
9.9
作者：
Bigal, M. E.;Ashina, S.;Lipton, R. B.
通讯作者：
Lipton, R. B.