Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.
Examination of N-hydroxylation as a prerequisite mechanism of nitric oxide synthase inactivation.
复制标题
检查 N-羟基化作为一氧化氮合酶失活的先决机制。
DOI：
10.1016/s0960-894x(00)00171-2
复制
发表时间：
2000
影响因子：
2.7
通讯作者：
Fung,HL
中科院分区：
文献类型：
--
作者：
Maurer,TS;Pan,J;Booth,BP;Kalman,TI;Fung,HL
l-N5-(1-Hydroxyiminoethyl)-ornithine (l-NHIO) and l-N6-(1-hydroxyiminoethyl)-lysine (l-NHIL) were synthesized and tested as potential intermediates in the mechanism-based inactivation of nitric oxide synthase (NOS) by l-N5-iminoethyl-ornithine (l-NIO) and l-N6-iminoethyllysine (l-NIL). Although these compounds were determined to be competitive inhibitors, mechanism-based inactivation was not observed.
