Enantioselective Synthesis of Tetrahydroindolizines via Ruthenium-Chiral Phosphoric Acid Sequential Catalysis
Enantioselective Synthesis of Tetrahydroindolizines via Ruthenium-Chiral Phosphoric Acid Sequential Catalysis
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钌-手性磷酸顺序催化对映选择性合成四氢吲嗪
作者：
Zhou Yong;Liu Xiao-Wei;Gu Qing;You Shu-Li
发现手性磷酸和钌络合物催化N-栓系烯烃吡咯和共轭烯酮的烯烃交叉复分解-不对称分子内Friedel-Crafts烷基化，以中等至良好的产率和对映选择性（高达93%ee）提供各种手性四氢中氮茚衍生物。
A chiral phosphoric acid and a ruthenium complex were found to catalyze an olefin cross-metathesis–asymmetric intramolecular Friedel–Crafts alkylation of N-tethered olefin pyrroles and conjugated enones to provide a variety of chiral tetrahydroindolizine derivatives in moderate to good yields and enantioselectivity (up to 93% ee).