The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.
The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.
复制标题
粟酒裂殖酵母 Hikeshi/Opi10 蛋白与其人类同源物具有相似的生化功能，但在不同的生理环境中发挥作用。
DOI：
10.1016/j.febslet.2014.04.018
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
N.
中科院分区：
文献类型：
--
作者：
Oda;Y.;Kimura;M.;Kose;S.;Fasken;M.B.;Corbett;A.H.;Imamoto;N.
人Hikeshi（HsHikeshi）是热休克蛋白70的核输入载体，是热休克后细胞存活所必需的。裂殖酵母中的Hikeshi同源物（SpHikeshi/Opi 10）定位于核边缘，与Hsp 70同源物Ssa 2相互作用，并介导其在重构的哺乳动物核转运系统中的核输入。然而，SpHikeshi/Opi 10不是热应激反应和热应激后生存所必需的。相反，SpHikeshi/Opi 10是在最佳条件下应激反应基因的正常表达和葡萄糖剥夺期间细胞生长所必需的。在这里，讨论了SpHikeshi/Opi 10的功能，并与HsHikeshi的功能进行了比较。
Human Hikeshi (HsHikeshi) is a nuclear import carrier for Hsp70s and is required for cell survival after heat shock. The Hikeshi homolog inSchizosaccharomyces pombe(SpHikeshi/Opi10) localizes to the nuclear rim, interacts with the Hsp70 homolog Ssa2, and mediates its nuclear import in a reconstituted mammalian nuclear transport system. However,SpHikeshi/Opi10 is not required for heat stress response and survival after heat stress. Instead,SpHikeshi/Opi10 is required for the normal expression of stress response genes under optimal conditions and for cell growth during glucose deprivation. Here, the functions ofSpHikeshi/Opi10 are discussed and compared to the functions ofHsHikeshi.