[Association of BCL9 expression with prostate cancer clinicopathological features and survival].
[Association of BCL9 expression with prostate cancer clinicopathological features and survival].
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DOI：
10.3760/cma.j.issn.0376-2491.2015.32.007
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发表时间：
2015-08
影响因子：
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通讯作者：
Guangning He;Sheng-bang Yang;Yan-ru Chen;Chao Cai;Y. Zhuo;Hong-wei Luo;Zhi-duan Cai;F. Jiang;Xiao-hui Ling
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文献类型：
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作者：
Guangning He;Sheng-bang Yang;Yan-ru Chen;Chao Cai;Y. Zhuo;Hong-wei Luo;Zhi-duan Cai;F. Jiang;Xiao-hui Ling
目的B细胞淋巴瘤9(Bcl9)作为β-连环蛋白介导的转录共激活因子，在肿瘤中高度表达。本研究旨在探讨bcl9在前列腺癌(PCa)中的表达及其临床病理意义。方法采用免疫组织化学方法检测98例PCa组织和20例良性前列腺增生症(BPH)组织中bcl9的表达。采用卡方检验、Kaplan-Meier法、LOG检验等统计方法，分析bcl9表达与PCa临床病理特征及预后的关系。结果前列腺癌组bcl9阳性率为53.1%(52/98)，良性组阳性率为25.0%(5/20)(P=0.022)。此外，bcl9在PCa组织中的表达与Gleason评分(P=0.016)和生化复发(P=0.020)显著相关。Kaplan-Meier生存分析显示bcl9高表达与无生化复发生存期短相关(P=0.037)。然而，经多因素分析后，bcl9不是PCa患者生化无复发生存率的独立预后因素(危险比=1.73，P=0.384)。结论bcl9基因表达上调与PCa的早期诊断及恶性程度有关。
OBJECTIVE B-cell lymphoma 9 (BCL9) as a co-activator for β-catenin-mediated transcription is highly expressed in tumors. The aim of our study is to investigate the expression of BCL9, and its clinicopathological significance in prostate cancer (PCa). METHODS Immunohistochemistry was conducted to analyze the expression of BCL9 in 98 PCa samples and 20 benign prostate hyperplasia (BPH) samples. The associations of BCL9 expression with clinicopathological features and prognosis in PCa patients were analyzed with various statistical methods, such as chi-square test, Kaplan-Meier method and log-rank test. RESULTS The positive rate of BCL9 was 53.1% (52/98) in prostate cancer group, and 25.0% (5/20) in benign group (P=0.022). In addition, BCL9 expression in PCa tissues was significantly associated with Gleason score (P=0.016), and biochemical recurrence (P=0.020). Moreover, Kaplan-Meier survival analysis showed that the higher expression of BCL9 was correlated with shorter biochemical recurrence-free survival (P=0.037). However, BCL9 was not an independent prognostic predictor for biochemical recurrence-free survival in patients with PCa after the multivariate analysis was conducted (Hazard ratio =1.73, P=0.384). CONCLUSION Our study demonstrates the up-regulation of BCL9 is associated with PCa's early diagnosis and malignant degree.