A Fluorescent Thin Film-Based Miniaturized Transcutaneous Carbon Dioxide Monitor
A Fluorescent Thin Film-Based Miniaturized Transcutaneous Carbon Dioxide Monitor
复制标题
基于荧光薄膜的微型经皮二氧化碳监测仪
DOI：
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
U. Guler
中科院分区：
文献类型：
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作者：
Tuna B. Tufan;U. Guler
动脉血气、氧气、二氧化碳和氢的电位是呼吸状态的关键指标，对于呼吸生命体征可能频繁和快速变化的患者，应持续监测。氧和二氧化碳的动脉分压可以用经皮监测来估计，经皮监测测量从皮肤扩散的氧和二氧化碳的分压。然而，传统的经皮血气监测仪需要加热元件和大型昂贵的床旁监测仪，这是其限制，妨碍了在临床环境之外的连续监测。因此，我们提出了一个小型化的荧光薄膜为基础的原型，设想作为第一个同类连续经皮二氧化碳监测可穿戴设备。计算原理依赖于测量二氧化碳敏感薄膜的荧光强度。原型监测器估计的二氧化碳分压范围为0至75 mmHg，涵盖了健康人的临床显著范围35-45 mmHg。该原型在60 mm×55 mm的印刷电路板上设计为小尺寸，功耗为64.33 mW，适合在进一步的设计阶段转化为可穿戴设备。
Arterial blood gases, oxygen, carbon dioxide, and the potential of hydrogen are the key indicators of respiratory status and should be continuously monitored for patients whose respiratory vital signs may alter frequently and rapidly. The arterial partial pressure of oxygen and carbon dioxide can be estimated with transcutaneous monitoring, which measures the partial pressure of oxygen and carbon dioxide diffusing from the skin. However, requiring a heating element and a large, expensive bedside monitor are the limitations of the traditional transcutaneous blood gas monitors preventing continuous monitoring outside a clinical setting. Therefore, we propose a miniaturized fluorescent thin film-based prototype, envisioned as a first-of-its-kind continuous transcutaneous carbon dioxide monitoring wearable device. The computation principle relies on measuring the fluorescence intensity of a carbon dioxide-sensitive thin film. The prototype monitor estimates the partial pressure of carbon dioxide ranging from 0 to 75 mmHg, covering the clinically significant range, 35–45 mmHg for healthy humans. The prototype is designed with a small form factor on a 60 mm×55 mm printed circuit board and consumes 64.33 mW, suitable to be translated into a wearable device in further design stages.