Family genetic studies, suicide, and suicidal behavior
Family genetic studies, suicide, and suicidal behavior
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DOI：
10.1002/ajmg.c.30042
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发表时间：
2005-02-15
影响因子：
3.1
通讯作者：
Mann, JJ
中科院分区：
文献类型：
--
作者：
Brent, DA;Mann, JJ
现存的通过，双胞胎，家庭研究自杀和自杀行为进行审查。自杀行为是高度家族性的，根据双胞胎和收养研究，也是遗传的。自杀完成者和自杀未遂者都是家庭传播的临床表型的一部分，因为自杀完成者的家庭成员中自杀未遂率升高，自杀完成者的家庭成员中自杀完成率升高。自杀行为的家族史与先证者的自杀行为相关，即使在先证者和家族中存在精神疾病的情况下进行调整后，也是如此，表明与精神疾病的家庭传播不同的尝试传播。先证者和家庭成员的冲动性攻击与自杀行为的家庭负荷相关，并可能导致自杀行为的家庭传播。其他可能的解释是共同的环境效应，如虐待、模仿或精神病理学的传播。(C)2005 Wiley-Liss，Inc.
The extant adoption, twin, and family studies of suicide and suicidal behavior are reviewed. Suicidal behavior is highly familial, and on the basis of twin and adoption studies, heritable as well. Both completed and attempted suicide form part of the clinical phenotype that is familially transmitted, as rates of suicide attempt are elevated in the family members of suicide completers, and completion rates are elevated in the family members of attempters. A family history of suicidal behavior is associated with suicidal behavior in the proband, even after adjusting for presence of psychiatric disorders in the proband and family, indicating transmission of attempt that is distinct from family transmission of psychiatric disorder. Impulsive aggression in probands and family members is associated with family loading for suicidal behavior, and may contribute to familial transmission of suicidal behavior. Shared environment effects such as abuse, imitation, or transmission of psychopathology are other possible explanations. (C) 2005 Wiley-Liss, Inc.