Hepatitis E antibody kinetics in Nepalese patients
Hepatitis E antibody kinetics in Nepalese patients
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DOI：
10.1016/j.trstmh.2005.12.005
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发表时间：
2006-10-01
影响因子：
2.2
通讯作者：
Scott, Robert McN.
中科院分区：
文献类型：
--
作者：
Myint, Khin Saw Aye;Endy, Timothy P.;Scott, Robert McN.
确定了 62 名患有急性戊型肝炎的尼泊尔成人队列，并使用沃尔特·里德陆军研究所 (WRAIR) 免疫测定法测定了戊型肝炎病毒 (HEV) 衣壳蛋白的总 Ig 和 IgM 水平。抗体谱是根据发病后 14 个月内收集的连续血清样本构建的。前3个月总Ig下降很快。随后出现缓慢、持续的下降，但抗体仍高于 20 WRAIR 单位的血清阳性水平。前 3 个月 IgM 下降幅度大于总 Ig，但 14 个月后 25% 的病例中 IgM 仍可检测到。研究数据有助于了解人类戊型肝炎的病理生理学，并设定抗体反应模式作为 HEV 疫苗开发的一部分。由爱思唯尔有限公司代表皇家热带医学与卫生学会出版。
A cohort of 62 Nepalese adults with acute hepatitis E was identified and total Ig as well as IgM levels to hepatitis E virus (HEV) capsid protein were determined using the Walter Reed Army Institute of Research (WRAIR) immunoassay. An antibody profile was constructed from serial serum specimens collected up to 14 months following the onset of illness. The decline in total Ig was rapid for the first 3 months. There followed a slow, sustained decline, but antibodies remained above the seropositive level of 20 WRAIR units. The decline of IgM was steeper than total Ig for the first 3 months, but IgM remained detectable after 14 months in 25% of cases. Study data contribute to an understanding of the pathophysiology of human hepatitis E and set an antibody response pattern to be targeted as a part of HEV vaccine development. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene.