Slow-5 dynamic functional connectivity reflects the capacity to sustain cognitive performance during pain
Slow-5 dynamic functional connectivity reflects the capacity to sustain cognitive performance during pain
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DOI：
10.1016/j.neuroimage.2017.06.005
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发表时间：
2017-08-15
期刊：
影响因子：
5.7
通讯作者：
Davis, K. D.
中科院分区：
文献类型：
--
作者：
Cheng, J. C.;Bosma, R. L.;Davis, K. D.
有些人在认知任务中比其他人更容易被疼痛分心，这代表了疼痛应对能力差。我们根据疼痛如何干扰任务速度，将个体分为A型（注意力占主导地位）或P型（疼痛占主导地位）。在疼痛期间优化行为的能力可能与执行控制网络的背外侧前额叶皮层（DLPFC）和显着网络（SN）的前中扣带皮层（aMCC）之间的休息时通信的灵活性有关-这些区域参与认知干扰。aMCC和aIns（SN集线器）也表示疼痛显著性;它们之间休息时的灵活通信可能允许在疼痛期间优先考虑任务性能。我们测试的假设，疼痛引起的任务表现的变化与这些区域对（DLPFC-aMCC; aMCC-aIns）之间的静息态动态功能连接（dFC）。我们发现，1）疼痛降低了P型个体的任务一致性/速度，但增强了A型个体的表现，2）任务一致性与DLPFC-aMCC和aMCC-aIns对中的FC动力学相关，3）大脑-行为关系由慢5（0.01-0.027 Hz）频带内的dFC驱动，4）大脑中的dFC在较高频率下降低。我们的研究结果指出，休息时的神经通信动力学与优先考虑任务表现而不是疼痛有关。
Some individuals are more distracted by pain during a cognitive task than others, representing poor pain coping. We have characterized individuals as A-type (attention dominates) or P-type (pain dominates) based on how pain interferes with task speed. The ability to optimize behavior during pain may relate to the flexibility in communication at rest between the dorsolateral prefrontal cortex (DLPFC) of the executive control network, and the anterior mid-cingulate cortex (aMCC) of the salience network (SN) - regions involved in cognitive-interference. The aMCC and aIns (SN hub) also signify pain salience; flexible communication at rest between them possibly allowing prioritizing task performance during pain. We tested the hypotheses that pain-induced changes in task performance are related to resting-state dynamic functional connectivity (dFC) between these region pairs (DLPFC-aMCC; aMCC-aIns). We found that 1) pain reduces task consistency/speed in P-type individuals, but enhances performance in A-type individuals, 2) task consistency is related to the FC dynamics within DLPFC-aMCC and aMCC-aIns pairs, 3) brain-behavior relationships are driven by dFC within the slow-5 (0.01-0.027 Hz) frequency band, and 4) dFC across the brain decreases at higher frequencies. Our findings point to neural communication dynamics at rest as being associated with prioritizing task performance over pain.