PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy
PEGylated Micelle Nanoparticles Encapsulating a Non-Fluorescent Near-Infrared Organic Dye as a Safe and Highly-Effective Photothermal Agent for In Vivo Cancer Therapy
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DOI：
10.1002/adfm.201301045
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发表时间：
2013-12-17
影响因子：
19
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Cheng, Liang;He, Weiwei;Liu, Zhuang
光热疗法(PTT)作为一种微创、高效的肿瘤治疗方法，近年来受到广泛关注。人们一直致力于探索各种具有高近红外(NIR)吸收的光热剂用于PTT癌症的治疗。尽管该领域取得了许多令人振奋的进展，但具有良好的生物相容性和生物降解性的有效而安全的光热剂仍然是人们迫切需要的。在这项工作中，开发了一种新的有机PTT试剂，该试剂基于聚乙二醇包覆的胶束纳米粒子包裹七甲基吲哚菁染料IR825，具有较强的近红外吸收带和较低的量子产率，用于体内光热治疗癌症。研究发现，IR825-聚乙二醇纳米粒在静脉注射后显示出超高的体内肿瘤摄取率，在低功率激光照射下似乎是一种良好的PTT消融剂，对治疗动物没有任何明显的毒性。与PTT中正在探索的无机纳米材料和共轭聚合物相比，本文提出的近红外吸收胶束纳米粒子可能具有最小的安全性，同时显示出良好的治疗效果，因此可能是一种潜在的临床应用的新型光热剂。
Photothermal therapy (PTT), as a minimally invasive and highly effective cancer treatment approach, has received widespread attention in recent years. Tremendous effort has been devoted to explore various types of photothermal agents with high near-infrared (NIR) absorbance for PTT cancer treatment. Despite many exciting progresses in the area, effective yet safe photothermal agents with good biocompatibility and biodegradability are still highly desired. In this work, a new organic PTT agent based on polyethylene glycol (PEG) coated micelle nanoparticles encapsulating a heptamethine indocyanine dye IR825 is developed, showing a strong NIR absorption band and a rather low quantum yield, for in vivo photothermal treatment of cancer. It is found that the IR825-PEG nanoparticles show ultra-high in vivo tumor uptake after intravenous injection, and appear to be an excellent PTT agent for tumor ablation under a low-power laser irradiation, without rendering any appreciable toxicity to the treated animals. Compared with inorganic nanomaterials and conjugated polymers being explored in PTT, the NIR-absorbing micelle nanoparticles presented here may have the least safety concern while showing excellent treatment efficacy, and thus may be a new photothermal agent potentially useful in clinical applications.