Carotid body tumors, inheritance, and a high incidence of associated cervical paragangliomas
Carotid body tumors, inheritance, and a high incidence of associated cervical paragangliomas
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DOI：
10.1016/s0002-9610(96)00151-1
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发表时间：
1996-08-01
影响因子：
3
通讯作者：
Miyamoto, R
中科院分区：
文献类型：
--
作者：
Gardner, P;Dalsing, M;Miyamoto, R
背景：目前对颈动脉体肿瘤的研究表明，颈副神经节瘤的高发率促使本文进行综述。患者和方法：对颈动脉体肿瘤患者进行了为期8年的回顾性研究，详细介绍了其表现、诊断和治疗。结果:11例患者共发现17例颈动脉体肿瘤，所有患者均有颈部肿块，7例患者（64%）有双侧颈动脉体肿瘤，6例（55%）有阳性家族史，其中4例为第一代亲属，5例双侧肿瘤，3例有其他头颈部副神经节瘤，血管造影显示除颈动脉体肿瘤外，4例伴有迷走神经和2例颈静脉球囊副神经节瘤，精确的手术护理将出血量限制在平均590毫升。颈动脉修复5例（29%），颅神经损伤3例，均为迷走体或颈静脉球切除术后，所有患者均存活，无脑卒中，功能无重大残疾。结论：颈动脉体肿瘤患者有多发头颈部副神经节瘤的倾向。血管造影是诊断，需要联合切除副神经节瘤显著增加脑神经损伤的风险。
BACKGROUND: Current experience with carotid body tumors suggesting a high prevalence of associated cervical paragangliomas prompted this review.PATIENTS AND METHODS: An 8-year retrospective study of patients with carotid body tumors was undertaken, detailing presentation, diagnosis, and treatment.RESULTS: Eleven patients harboring 17 carotid body tumors were discovered, Ail patients had a neck mass, Seven patients (64%) had bilateral carotid body tumors, Six (55%) reported a positive family history-4 were first-generation relatives, 5 had bilateral tumors, and 3 had other head and neck paragangliomas, Angiography documented 4 associated vagal and 2 glomus jugulare paragangliomas in addition to the carotid body tumors, Precise surgical care limited blood loss to an average of 590 cc, The carotid artery was repaired during 5 resections (29%), Cranial nerve injury occurred in 3 cases, all following vagal body or glomus jugulare resection, Every patient is currently alive, stroke free, and functioning without major disability.CONCLUSIONS: Patients with carotid body tumors have a propensity for multiple head and neck paragangliomas. Angiography is diagnostic, The need for associated paraganglioma resection dramatically increases the risk of cranial nerve injury.