On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance
On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance
复制标题
DOI：
10.1371/journal.pone.0177042
复制
发表时间：
2017-05-04
期刊：
影响因子：
3.7
通讯作者：
Holtermann, Andreas
中科院分区：
文献类型：
--
作者：
Hallman, David M.;Jorgensen, Marie Birk;Holtermann, Andreas
休闲时间体力活动（LTPA）对心血管健康和长寿有相当大的好处，而职业体力活动（OPA）与心血管风险升高有关。这种“健康悖论”可能是由于OPA和LTPA对自主神经系统的不同影响。因此，我们的目的是调查是否客观测量OPA和LTPA与自主调节workers.MethodsThe研究包括514蓝领工人从丹麦队列DPHACTO之间的差异。在多个工作日内，使用佩戴在大腿、臀部和躯干上的加速度计客观评估身体活动（即步行、爬楼梯、跑步和骑自行车）。在此期间，使用心率监测器从ECG信号中采样心动周期间隔。心率和心率变异性（HRV）指数在夜间睡眠作为自主调节的标志进行了分析。多元回归分析用于确定OPA和LTPA的主要影响及其对心率和HRV的相互作用，调整多个混杂因素。
ObjectiveLeisure-time physical activity (LTPA) has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA) is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous system from OPA and LTPA. Thus, we aimed to investigate whether objectively measured OPA and LTPA are differentially associated with autonomic regulation among workers.MethodsThe study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling) was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV) indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.ResultsStatistically significant interaction was found between OPA and LTPA on heart rate (adjusted p