Disposition and Metabolism of MHPG in Humans: Application to Studies in Depression
Disposition and Metabolism of MHPG in Humans: Application to Studies in Depression
复制标题
人类 MHPG 的处置和代谢：在抑郁症研究中的应用
DOI：
10.1055/s-2007-1017399
复制
发表时间：
1984
影响因子：
4.3
通讯作者：
R. Polinsky
中科院分区：
文献类型：
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作者：
I. Kopin;D. Jimerson;S. Markey;M. Ebert;R. Polinsky
MHPG由全身代谢的去甲肾上腺素形成;其在血浆中的水平反映了总的去甲肾上腺素代谢。超过一半的MHPG被转换为VMA。不到20%的MHPG来自脑去甲肾上腺素，该代谢物的尿排泄不能用作脑去甲肾上腺素代谢的指标。由于未结合的MHPG易于扩散，因此该代谢物在血浆、脑脊液和神经组织（包括脑和脊髓）之间自由交换。适当校正代谢产物的血浆贡献后，CSF MHPG水平反映了其在中枢神经系统中的形成速率。
MHPG is formed from norepinephrine metabolized throughout the body; its levels in plasma reflect total norepinephrine metabolism. Over half of the MHPG, is converted to VMA. Less than 20% of MHPG is derived from brain norepinephrine and urinary excretion of this metabolite cannot be used as a measure of brain norepinephrine metabolism. Because unconjugated MHPG is readily diffusable, there is a free exchange of this metabolite among plasma, cerebrospinal fluid, and nerve tissues (including brain and spinal cord). The CSF MHPG levels, after appropriately correction for the plasma contribution of the metabolite, reflect its rate of formation in the central nervous system.
影响因子：
--
作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young