Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
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DOI：
10.1016/j.ahj.2003.07.006
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发表时间：
2004-01-01
影响因子：
4.8
通讯作者：
Vincent, JL
中科院分区：
文献类型：
--
作者：
De Backer, D;Creteur, J;Vincent, JL
背景：微血管血流改变可能损害组织氧合，并可能参与严重心力衰竭患者多器官功能衰竭的发展。我们假设，微血管血流改变是目前在严重的心力衰竭和心源性shock.Methods患者，我们采用正交偏振光谱成像技术，探讨舌下微循环在40例急性严重心力衰竭，其中3 - 1例心源性休克，并在对照组的15例患者进行了心脏手术前一天检查。对5例心源性休克病人局部应用乙酰胆碱（10 ~（-2）M）也进行了观察。五个舌下区域被记录，分配一个随机数字，后来进行半定量分析。结果3组血管密度无显著性差异（P > 0. 05）。小分子量聚乙烯（
Background Microvascular blood flow alterations may impair tissue oxygenation and may participate in the development of multiple organ failure in patients with severe heart failure. We hypothesized that microvascular blood flow alterations are present in patients with severe heart failure and cardiogenic shock.Methods We used an orthogonal polarization spectral imaging technique to investigate the sublingual microcirculation in 40 patients with acute severe heart failure, including 3 1 patients with cardiogenic shock, and in a control group of 15 patients who were examined the day before cardiac surgery. The effects of topical application of acetylcholine (10-2M) were also tested in 5 patients with cardiogenic shock. Five sublingual areas were recorded, allocated a random number, and later analyzed semiquantitatively. Data were analyzed with non-parametric tests and presented as medians (percentiles 25-75).Results The density of all the vessels was similar in the 3 groups. The proportion of perfused small (