The 3' UTR elements of P. gallinaceum protein Pgs28 are functionally distinct from those of human cells.
The 3' UTR elements of P. gallinaceum protein Pgs28 are functionally distinct from those of human cells.
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P. gallinaceum 蛋白 Pgs28 的 3 UTR 元件在功能上与人类细胞的不同。
DOI：
10.1016/j.molbiopara.2004.07.001
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Golightly,LinnieM
中科院分区：
文献类型：
--
作者：
Shue,Peter;Brown,SilviaV;Cann,Helen;Singer,EsmeF;Appleby,Susan;Golightly,LinnieM
Plasmodium parasites are major causes of morbidity and mortality worldwide. Despite this, their mechanisms of gene regulation have only recently begun to be elucidated [1, 2]. Several studies have shown that Plasmodium species require parasite-specific 5′ promoter and 3′ gene regulatory elements for protein expression [3–5]. These findings suggest that understanding the differences between the gene regulatory mechanisms of Plasmodium and those of man could permit the development of novel parasite-specific chemotherapeutics targeting the parasite’s gene regulatory apparatus. While strides have been made in defining the 5′ promoter elements of Plasmodium, the cis-acting elements in the 3′ UTR elements remain poorly defined [1, 5, 6]. Similarities between the 3′ gene regulatory domains of Plasmodium and those of metazoans, however, have been noted. In metazoans, cleavage and polyadenylation of mRNA occurs 10–30 nucleotides 3′ of a hexamer motif (AATAAA/ATTAAAA)Abbreviations: P. gallinaceum, Plasmodium gallinaceum; P. falciparum,
