Three-dimensional and ultrastructural ICAM-1 distribution in the choroid plexus, arachnoid membrane and dural sinus of inflammatory rats induced by LPS injection in the lateral ventricles
Three-dimensional and ultrastructural ICAM-1 distribution in the choroid plexus, arachnoid membrane and dural sinus of inflammatory rats induced by LPS injection in the lateral ventricles
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DOI：
10.1016/s0006-8993(98)00042-0
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发表时间：
1998-05-18
期刊：
影响因子：
2.9
通讯作者：
Kayama, T
中科院分区：
文献类型：
--
作者：
Endo, H;Sasaki, K;Kayama, T
为探讨脑脊液（CSF）系统的免疫环境，采用免疫扫描电镜（sem）和透射电镜（TEM）研究了lps刺激大鼠脉络膜丛、蛛网膜和硬脑膜窦中细胞间粘附分子-1 （ICAM-1）的超微结构和三维定位。脉络膜丛上皮细胞沿微绒毛表达丰富的ICAM-1。蛛网膜小梁成纤维细胞样细胞在面向蛛网膜下腔的两侧均有ICAM-1表达。而硬脑膜窦内皮细胞仅表达少量ICAM-1，且无特异性定位。这些结果提示，脉络丛和蛛网膜可能在脑脊液系统中对白细胞的迁移起着重要的相互作用，脑脊液系统可能通过上调ICAM-1表达而独立于血管系统进行免疫反应。(C) 1998 Elsevier Science B.V.版权所有
To investigate immunological environment in the cerebrospinal fluid (CSF) system, ultrastructural and three-dimensional localization of intercellular adhesion molecule-1 (ICAM-1) was studied in the choroid plexus, arachnoid membrane and dural sinus of LPS-stimulated rats with immuno-SEM and TEM. The choroid plexus epithelial cells expressed rich ICAM-1 along the microvilli. The arachnoid trabeculae fibroblast-like cells demonstrated ICAM-1 expression on both sides facing the subarachnoid space moderately. The dural sinus endothelial cells, however, showed only few ICAM-1 expression and no specific localization. These results suggest that the choroid plexus and arachnoid membrane may play an important mutual role for leukocyte migration in the CSF system, and that the CSF system may function in immunoreaction independently of the vascular system with the aid of up-regulated ICAM-1 expression. (C) 1998 Elsevier Science B.V. All rights reserved.