The relationship between social cognition and executive function in Major Depressive Disorder in high-functioning adolescents and young adults
The relationship between social cognition and executive function in Major Depressive Disorder in high-functioning adolescents and young adults
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DOI：
10.1016/j.psychres.2018.02.046
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发表时间：
2018-05-01
影响因子：
11.3
通讯作者：
Baune, Bernhard T.
中科院分区：
文献类型：
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作者：
Foerster, Katharina;Joergens, Silke;Baune, Bernhard T.
为了了解认知功能障碍如何导致抑郁症患者的社会认知缺陷，我们调查了青少年和年轻人在当前和缓解抑郁症期间的执行功能和社会认知表现之间的关系，并与健康对照组进行了比较。对179名学生（健康对照61名，抑郁症患者118名；M-age = 20.60岁；SDage = 3.82岁）的社会认知和执行功能进行了测量。在每一组（健康对照组、抑郁症缓解组、当前抑郁症组）中采用层次回归模型来检验认知测量之间关联的本质。抑郁症患者和健康对照组的社会认知和执行功能总体上没有显著差异。在健康对照组和缓解患者中，执行功能和社会认知功能之间没有关联。然而，在当前抑郁状态的患者中，认知灵活性较低与面部情感识别、心理理论任务和整体情感识别的表现较差相关。在这一组中，更好的计划能力与面部情感识别和整体社会认知表现的下降有关。虽然我们推断认知灵活性的降低可能导致对模糊社会刺激的更严格的解释，但我们将计划能力和社会认知的反直觉负相关解释为一种补偿机制。
To understand how cognitive dysfunction contributes to social cognitive deficits in depression, we investigated the relationship between executive function and social cognitive performance in adolescents and young adults during current and remitted depression, compared to healthy controls. Social cognition and executive function were measured in 179 students (61 healthy controls and 118 patients with depression; M-age = 20.60 years; SDage = 3.82 years). Hierarchical regression models were employed within each group (healthy controls, remitted depression, current depression) to examine the nature of associations between cognitive measures. Social cognitive and executive function did not significantly differ overall between depressed patients and healthy controls. There was no association between executive function and social cognitive function in healthy controls or in remitted patients. However, in patients with a current state of depression, lower cognitive flexibility was associated with lower performance in facial-affect recognition, theory-of-mind tasks and overall affect recognition. In this group, better planning abilities were associated with decreased performance in facial affect recognition and overall social cognitive performance. While we infer that less cognitive flexibility might lead to a more rigid interpretation of ambiguous social stimuli, we interpret the counterintuitive negative correlation of planning ability and social cognition as a compensatory mechanism.