THE ROLE OF THE MATRIX METALLOPROTEINASE STROMELYSIN IN THE PROGRESSION OF SQUAMOUS-CELL CARCINOMAS
THE ROLE OF THE MATRIX METALLOPROTEINASE STROMELYSIN IN THE PROGRESSION OF SQUAMOUS-CELL CARCINOMAS
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DOI：
10.1097/00000441-199109000-00008
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发表时间：
1991-09-01
影响因子：
3.1
通讯作者：
HENDRIX, MJC
中科院分区：
文献类型：
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作者：
MATRISIAN, LM;MCDONNELL, S;HENDRIX, MJC
金属蛋白酶基质分解蛋白的表达与化学诱导的鳞状细胞癌的进展有关。我们证明，在乳头状瘤来源的细胞中，激活的基质分解素的表达增强了体外细胞的侵袭性。我们还证明，Ha-ras癌基因通过AP-1依赖的途径诱导基质分解素基因的转录。假说是癌基因和抑制基因的改变影响基质分解素的表达，从而影响肿瘤侵袭和转移的后续步骤。
The expression of the metalloproteinase stromelysin correlates with the progression of chemically induced squamous cell carcinomas. We demonstrate that the expression of activated stromelysin in papilloma-derived cells enhances in vitro cell invasion. We also demonstrate that the Ha-ras oncogene induces the transcription of the stromelysin gene through an AP-1 dependent pathway. The hypothesis is that alterations in oncogenes and suppressor genes influence stromelysin expression and thus influence subsequent steps of tumor invasion and metastasis.