Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
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DOI：
10.1016/j.biomaterials.2012.11.040
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发表时间：
2013-03-01
期刊：
影响因子：
14
通讯作者：
Lythgoe, Mark F.
中科院分区：
文献类型：
--
作者：
Riegler, Johannes;Liew, Aaron;Lythgoe, Mark F.
血管闭塞可导致致命的心肌梗塞、中风或外周动脉疾病导致肢体丧失。介入球囊血管成形术是治疗血管疾病的常见一线手术，但长期成功受到再狭窄和新内膜增生的限制。已提出细胞疗法来缓解这些问题；然而功效较低，部分原因是细胞保留不良。我们发现，在使用临床适用的永磁体对兔模型进行球囊血管成形术后，间充质干细胞的磁性靶向可使细胞保留增加 6 倍。用超顺磁性氧化铁纳米颗粒标记的细胞对细胞活力、分化或分泌模式没有负面影响。干细胞保留的增加导致细胞交付三周后再狭窄的减少。 (C) 2012 Elsevier Ltd. 保留所有权利。
Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. (C) 2012 Elsevier Ltd. All rights reserved.