Rodent models for HIV-associated neurocognitive disorders.
Rodent models for HIV-associated neurocognitive disorders.
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DOI：
10.1016/j.tins.2011.12.006
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发表时间：
2012-03
影响因子：
15.9
通讯作者：
Gendelman HE
中科院分区：
文献类型：
--
作者：
Gorantla S;Poluektova L;Gendelman HE
人类免疫缺陷病毒（HIV）相关的神经认知障碍（HAND）反映了慢性病毒感染期间观察到的神经损伤谱。目前的研究工作集中在改善抗逆转录病毒和抗逆转录病毒疗法，确定疾病的发作和进展，促进药物输送，并阻止神经变性和病毒耐药性。由于艾滋病毒是物种特异性的，在小动物模型中产生疾病已被证明具有挑战性。经过二十年的研究，啮齿动物HAND模型现在包括那些含有人类免疫系统的模型。在这些啮齿动物模型中，HIV感染后出现抗病毒反应、神经炎症和免疫细胞血脑屏障（BBB）运输。在这里，我们回顾这些和其他啮齿类动物模型的手，并讨论其未满足的潜力，反映人类的病理生物学和促进疾病监测和治疗的发现。
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) reflect the spectrum of neural impairments seen during chronic viral infection. Current research efforts focus on improving antiretroviral and adjunctive therapies, defining disease onset and progression, facilitating drug delivery, and halting neurodegeneration and viral resistance. As HIV is species-specific, generating disease in small animal models has proved challenging. After two decades of research, rodent HAND models now include those containing a human immune system. Antiviral responses, neuroinflammation and immunocyte blood-brain barrier (BBB) trafficking follow HIV infection in these rodent models. Here, we review these and other rodent models of HAND and discuss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and therapeutic discoveries.