Autoradiographic localization of 3H-dihydrotestosterone in the preoptic area, hypothalamus, and amygdala of a male rhesus monkey.
Autoradiographic localization of 3H-dihydrotestosterone in the preoptic area, hypothalamus, and amygdala of a male rhesus monkey.
复制标题
雄性恒河猴视前区、下丘脑和杏仁核中 3H-二氢睾酮的放射自显影定位。
DOI：
10.1016/0024-3205(82)90450-7
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
H. Rees
中科院分区：
文献类型：
--
作者：
Richard P. Michael;H. Rees
在一项初步研究中，放射自显影术被用于定位恒河猴脑中3 H-二氢睾酮（DHT）（一种非芳香化雄激素）的靶细胞。一只去势雄性大鼠静脉注射2 mCi的3 H-DHT0.42 μg/kg，1h后处死。在其核中集中放射性的神经元位于大脑的广泛区域，包括内侧和视交叉上视前核、终纹床核、外侧隔核、下丘脑前区、腹内侧、弓状或背内侧核和室旁下丘脑核、腹侧乳头体前核以及内侧、皮质、基底副核和外侧杏仁核。这些结果表明，雄激素靶神经元的地形分布比在雄性恒河猴中使用3 H-睾酮（T）的研究中观察到的分布要宽得多（1）。然而，在尝试行为活动和大脑中雄激素受体之间的相关性之前，需要进一步的工作来阐明这些差异。
In a preliminary study, autoradiography was used to localize target cells for3Hdihydrotestosterone (DHT), a non-aromatizable androgen, in the brain of the rhesus monkey. One castrated male was injected intravenously with 2 mCi of3HDHT (0.42 μg/kg), and was killed one hour later. Neurons that concentrated radioactivity in their nuclei were located in widespread areas of the brain, which included the medial and suprachiasmatic preoptic nuclei, bed nucleus of the stria terminalis, lateral septal nucleus, anterior hypothalamic area, ventromedial, arcuate, or dorsemedial, and paraventricular hypothalamic nuclei, ventral premammillary nucleus, and medial, cortical, basal accessory, and lateral amygdaloid nuclei. These results indicate that the topographic distribution of androgen target neurons is considerably wider than that observed in a study using3Htestosterone (T) in the male rhesus monkey (1). However, further work is needed to elucidate these differences before attempting correlations between behavioral activity and androgen receptors in the brain.