Correlation of Plasma and Synovial Fluid Adiponectin with Knee Osteoarthritis Severity
Correlation of Plasma and Synovial Fluid Adiponectin with Knee Osteoarthritis Severity
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DOI：
10.1016/j.arcmed.2010.11.007
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发表时间：
2010-11-01
影响因子：
7.7
通讯作者：
Chayanupatkul, Maneerat
中科院分区：
文献类型：
--
作者：
Honsawek, Sittisak;Chayanupatkul, Maneerat
背景和目标。骨关节炎（OA）是一种滑膜关节的慢性退行性关节疾病，其特征是关节软骨丢失、骨赘形成和软骨下骨改变。本研究旨在检测膝关节OA患者血浆和滑液中脂联素的浓度，并分析脂联素水平与疾病严重程度的相关性。76名OA患者（平均年龄69.8 ± 1.1岁）和24名健康对照（平均年龄71.2 ± 1.5岁）入组本研究。通过评估膝关节前后位X线片中观察到的X线变化，使用Kelling-Lawrence（KL）标准进行OA分级。采用酶联免疫吸附法测定血浆和关节液中脂联素水平。与健康个体相比，OA患者的脂联素血浆水平较高，但差异未达到统计学显著性（2428.0 +/- 245.1 vs. 2030.3 +/- 399.4 ng/mL，p = 0.4）。血浆脂联素水平明显高于配对滑液（2428.0 +/- 245.1 vs. 301.3 +/- 44.9 ng/mL，p
Background and Aims. Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. The purposes of this study were to measure adiponectin concentrations in plasma and synovial fluid of patients with knee OA and to analyze the correlation of adiponectin levels with disease severity.Methods. Seventy six OA patients (mean age 69.8 +/- 1.1 years) and 24 healthy controls (mean age 71.2 +/- 1.5 years) were enrolled in this study. OA grading was performed using the Kellgren-Lawrence (KL) criteria by evaluating x-ray changes observed in anteroposterior knee radiography. Adiponectin levels in plasma and synovial fluid were determined by commercial enzyme-linked immunosorbent assay.Results. Plasma levels of adiponectin were higher in OA patients compared to healthy individuals, but the difference did not reach statistical significance (2428.0 +/- 245.1 vs. 2030.3 +/- 399.4 ng/mL, p = 0.4). Adiponectin levels in plasma were remarkably higher with regard to paired synovial fluid (2428.0 +/- 245.1 vs. 301.3 +/- 44.9 ng/mL, p