Influence of Gd-EOB-DTPA on proton density fat fraction using the six-echo Dixon method in 3 Tesla magnetic resonance imaging
Influence of Gd-EOB-DTPA on proton density fat fraction using the six-echo Dixon method in 3 Tesla magnetic resonance imaging
复制标题
DOI：
10.1007/s12194-017-0420-7
复制
发表时间：
2017-12-01
影响因子：
1.6
通讯作者：
Oba, Hiroshi
中科院分区：
文献类型：
--
作者：
Hayashi, Tatsuya;Fukuzawa, Kei;Oba, Hiroshi
本研究的目的是评估Gd-EOB-DTPA(Gd-EOB-DTPA)在体模中使用MultiECHO Dixon(MeDixon)方法时对质子密度脂肪部分(PDF)的影响，并在3个T的模拟磁共振成像(MRI)研究中进行。没有Gd-EOB-DTPA的模体定义为平扫，有Gd-EOB-DTPA的模体定义为后对比。所有模型均采用meDixon方法在3T磁共振系统上进行扫描，并计算增强前后的PDF。使用理论公式计算肝脏中模拟的增强前后的PDF。用线性回归和Bland-Altman分析评价增强前后体模测量的PDF之间的关系。对比增强前后的PDF的回归分析得出斜率为0.77(P<；0.001)。增强后体模上的PDF比增强前体模上的小。增强前后模型的平均差值为6.12%(95%可信区间为3.13~9.10%；一致性限为-0.88~13.11%)。增强后体模上的模拟PDFF比增强前体模上的小。我们证明，如果使用低翻转角，在3T时，使用meDixon测量的PDFF在增强后比平扫时要小。这一趋势也体现在模拟研究结果中。
The purpose of this study was to evaluate whether disodium gadoxetate (Gd-EOB-DTPA) affects proton density fat fractions (PDFFs) during use of the multiecho Dixon (meDixon) method in phantom and simulation magnetic resonance imaging (MRI) studies at 3 T. Fat-water phantoms comprising vegetable fat-water emulsions with varying fat volume percentages (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-DTPA concentrations (0 and 0.4 mM) were prepared. Phantoms without Gd-EOB-DTPA were defined as precontrast, and those with Gd-EOB-DTPA were defined as postcontrast. All phantoms were scanned with a 3 T MRI system using the meDixon method, and precontrast and postcontrast PDFFs were calculated. Simulated pre and postcontrast PDFFs in the liver were calculated using a theoretical formula. The relationship between PDFFs measured in the pre and postcontrast phantoms was evaluated using linear regression and Bland-Altman analysis. The regression analysis comparing the pre and postcontrast PDFFs yielded a slope of 0.77 (P < 0.001). The PDFFs on the postcontrast phantom were smaller than those on the precontrast phantom. The mean difference between the PDFFs on the pre and postcontrast phantoms was 6.12% (95% confidence interval 3.13 to 9.10%; limits of agreement -0.88 to 13.11%). The simulated PDFF on the postcontrast phantom was smaller than that on the precontrast phantom. We demonstrated that the PDFF measured using the meDixon was smaller on postcontrast than on precontrast at 3 T, if a low flip angle was used. This tendency was also seen in the simulation study results.