Importance of Kupffer cells in the development of acute liver injuries in mice.
Importance of Kupffer cells in the development of acute liver injuries in mice.
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DOI：
10.3390/ijms15057711
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发表时间：
2014-05-05
影响因子：
5.6
通讯作者：
Nishiguchi S
中科院分区：
文献类型：
--
作者：
Tsutsui H;Nishiguchi S
枯否细胞位于肝窦状隙内，充当看门人。它们在模式识别受体如Toll样受体的参与下产生促炎和抗炎细胞因子和其他生物学重要分子。通过氯膦酸盐脂质体体内治疗建立的枯否细胞消融小鼠揭示了枯否细胞的许多重要特征。本文综述了枯否细胞在小鼠急性肝损伤中的重要作用，重点介绍了两种模型：脂多糖（LPS）诱导的肝损伤（由痤疮丙酸杆菌引发，随后用LPS激发）和高凝状态介导的急性肝衰竭（如刀豆球蛋白A（ConA）诱导的肝炎）。枯否细胞是痤疮丙酸杆菌诱导的LPS致敏所必需的，并且是白细胞介素-18的主要细胞来源，其在LPS攻击后诱导急性肝损伤。枯否细胞通过与窦状隙内皮细胞合作启动致病性窦内血栓形成而促成Con A诱导的急性肝衰竭。这些模型的机制可能揭示了人类肝脏损伤诱导的各种病因，如病毒感染和/或代谢异常。
Kupffer cells reside within the liver sinusoid and serve as gatekeepers. They produce pro- and anti-inflammatory cytokines and other biologically important molecules upon the engagement of pattern recognition receptors such as Toll-like receptors. Kupffer cell-ablated mice established by in vivo treatment with clodronate liposomes have revealed many important features of Kupffer cells. In this paper, we review the importance of Kupffer cells in murine acute liver injuries and focus on the following two models: lipopolysaccharide (LPS)-induced liver injury, which is induced by priming with Propionibacterium acnes and subsequent challenge with LPS, and hypercoagulability-mediated acute liver failure such as that in concanavalin A (Con A)-induced hepatitis. Kupffer cells are required for LPS sensitization induced by P. acnes and are a major cellular source of interleukin-18, which induces acute liver injury following LPS challenge. Kupffer cells contribute to Con A-induced acute liver failure by initiating pathogenic, intrasinusoidal thrombosis in collaboration with sinusoidal endothelial cells. The mechanisms underlying these models may shed light on human liver injuries induced by various etiologies such as viral infection and/or abnormal metabolism.
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影响因子：
4.4
作者：
Kalis, C;Gumenscheimer, M;Freudenberg, MA
通讯作者：
Freudenberg, MA
DOI：
10.1084/jem.20120340
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hoeffel G;Wang Y;Greter M;See P;Teo P;Malleret B;Leboeuf M;Low D;Oller G;Almeida F;Choy SH;Grisotto M;Renia L;Conway SJ;Stanley ER;Chan JK;Ng LG;Samokhvalov IM;Merad M;Ginhoux F
通讯作者：
Ginhoux F
影响因子：
4.1
作者：
Ju, C;Reilly, TP;Pohl, LR
通讯作者：
Pohl, LR
影响因子：
20.3
作者：
Lisman, Ton;Porte, Robert J.
通讯作者：
Porte, Robert J.
影响因子：
13.5
作者：
Bourdi, M;Masubuchi, Y;Pohl, LR
通讯作者：
Pohl, LR