Vascular and epithelial junctions: a barrier for leucocyte migration
Vascular and epithelial junctions: a barrier for leucocyte migration
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DOI：
10.1042/bst0360203
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发表时间：
2008-04-01
影响因子：
3.9
通讯作者：
Imhof, Beat A.
中科院分区：
文献类型：
--
作者：
Garrido-Urbani, Sarah;Bradfield, Paul F.;Imhof, Beat A.
白细胞通过内皮和上皮屏障的快速动员是免疫系统反应性的关键。调节这些过程的潜在机制是最近许多研究的基础。传统上认为，白细胞外渗是通过细胞旁途径发生的，这涉及内皮细胞连接的局部破坏。然而，最近，已经描述了涉及通过内皮细胞体的跨细胞途径。白细胞也能够通过上皮细胞迁移以监测粘膜组织和微环境。已知许多粘附分子调节白细胞通过细胞和内皮层的迁移。细胞旁和跨细胞白细胞迁移受粘附分子如PECAM-1（血小板-内皮细胞粘附分子1）、CD 99、VE-钙粘蛋白（血管内皮钙粘蛋白）和JAM（连接粘附分子）蛋白调节。这篇综述的目的是讨论这些分子在白细胞迁移中的作用，以及它们如何促进调节白细胞运输的不同机制。
Rapid mobilization of leucocytes through endothelial and epithelial barriers is key in immune system reactivity. The underlying mechanisms that regulate these processes have been the basis for many recent studies. Traditionally, leucocyte extravasation had been believed to occur through a paracellular route, which involves localized disruption of endothelial cell junctions. However, more recently, a transcellular route has been described involving the passage through the endothelial cell body. Leucocytes are also able to migrate through epithelium to monitor mucosal tissues and microenvironments. A number of adhesion molecules are known to regulate transmigration of leucocytes through ell and endothelial layers. Paracellular and transcellular leucocyte transmigration are regulated by adhesion molecules such as PECAM-1 (platelet-endothelial cell adhesion molecule 1), CD99, VE-cadherin (vascular endothelial cadherin) and JAM (junctional adhesion molecule) proteins. The purpose of this review is to discuss the role of these molecules in leucocyte transmigration and how they contribute to the different mechanisms that regulate leucocyte trafficking.