Diversification of Potassium Currents in Excitable Cells via Kvβ Proteins.
Diversification of Potassium Currents in Excitable Cells via Kvβ Proteins.
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神经和心血管系统的兴奋细胞依赖于质膜钾通道的分类来控制不同的细胞功能。电压门控钾离子通道是这些过程中膜兴奋性反馈控制的核心，因为它们被允许K+流出的去极化膜电位激活。因此，KV电流不仅受到影响通道丰度和形状电压敏感性的众多细胞信号传导范例的差异控制，而且还受到通道复合物的异聚体构型的差异控制。在这种情况下，我们讨论了目前的知识，细胞内Kvβ蛋白如何与孔复合物的振动相关的Kv1通道相互作用，可能会建立一个可修改的兴奋性和代谢状态之间的联系。过去在异源系统中的研究表明Kvβ蛋白在调节通道稳定性、运输、亚细胞靶向和门控中的作用。最近的作品，确定潜在的体内生理作用被认为是在这些早期的研究和知识的关键差距，以解决未来的研究进行了说明。
Excitable cells of the nervous and cardiovascular systems depend on an assortment of plasmalemmal potassium channels to control diverse cellular functions. Voltage-gated potassium (Kv) channels are central to the feedback control of membrane excitability in these processes due to their activation by depolarized membrane potentials permitting K+ efflux. Accordingly, Kv currents are differentially controlled not only by numerous cellular signaling paradigms that influence channel abundance and shape voltage sensitivity, but also by heteromeric configurations of channel complexes. In this context, we discuss the current knowledge related to how intracellular Kvβ proteins interacting with pore complexes of Shaker-related Kv1 channels may establish a modifiable link between excitability and metabolic state. Past studies in heterologous systems have indicated roles for Kvβ proteins in regulating channel stability, trafficking, subcellular targeting, and gating. More recent works identifying potential in vivo physiologic roles are considered in light of these earlier studies and key gaps in knowledge to be addressed by future research are described.
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