Preparation of Temperature- and pH-Sensitive, Stimuli- Responsive Poly(N-isopropylacrylamide-co-methacrylic acid) Nanoparticles
Preparation of Temperature- and pH-Sensitive, Stimuli- Responsive Poly(N-isopropylacrylamide-co-methacrylic acid) Nanoparticles
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DOI：
10.1002/app.27888
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发表时间：
2008-05
影响因子：
3
通讯作者：
P. Tian;Qinglin Wu;K. Lian
中科院分区：
文献类型：
--
作者：
P. Tian;Qinglin Wu;K. Lian
用傅里叶变换红外光谱、差示扫描量热法和动态激光散射技术研究了单体配比、表面活性剂和交联剂含量对N-异丙基丙烯酰胺-甲基丙烯酸共聚物（PNIPAAm-MAA）粒径和相转变行为的影响。除了聚（N-异丙基丙烯酰胺）的温敏特性之外，离子化的甲基丙烯酸基团给PNIPAAm-MAA共聚物颗粒带来pH敏感性。聚合物粒径随单体配比、表面活性剂和交联剂的用量而变化.随着单体配比和交联剂含量的增加以及表面活性剂用量的减少，粒径增大。交联剂含量对粒径的影响不如单体配比和表面活性剂的影响显著。当温度升高时，颗粒趋于收缩并且尺寸减小至接近或低于100 nm。随着表面活性剂含量的增加，208 ℃下的颗粒尺寸减小至小于100 nm。将粒径控制在100 nm范围内使得PNIPAAm-MAA共聚物颗粒可用于生物医学和重金属离子吸附应用。2008 Wiley Periodicals，Inc. J Appl Polym Sci 108：2226-2232，2008
The effects of the monomer ratio, surfac- tant, and crosslinker contents on the particle size and phase-transition behavior of the copolymer poly(N-isopro- pylacrylamide-co-methacrylic acid) (PNIPAAm-MAA) were investigated with Fourier transform infrared, differ- ential scanning calorimetry, and dynamic laser scattering techniques. In addition to the thermoresponsive property of poly(N-isopropylacrylamide), ionized methacrylic acid groups brought pH sensitivity to the PNIPAAm-MAA co- polymer particles. The polymer particle size varied with the amounts of the monomer ratio, surfactant, and cross- linker. As the monomer ratio and crosslinker content increased and the amount of the surfactants decreased, the particle size increased. The influence of the crosslinker content on the particle size was less significant than the effect of the monomer ratio and surfactants. When the temperature increased, the particles tended to shrink and decreased in size to near or below 100 nm. Particle sizes at 208C decreased to less than 100 nm with increased surfac- tant content. The control of the particle size within the 100-nm range makes PNIPAAm-MAA copolymer particles useful for biomedical and heavy-metal-ion adsorption applications. 2008 Wiley Periodicals, Inc. J Appl Polym Sci 108: 2226-2232, 2008