Electrospun biodegradable nanofibers loaded with epigallocatechin gallate for guided bone regeneration
Electrospun biodegradable nanofibers loaded with epigallocatechin gallate for guided bone regeneration
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负载表没食子儿茶素没食子酸酯的电纺可生物降解纳米纤维用于引导骨再生
DOI：
10.1016/j.compositesb.2022.109920
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Youcheng Yu
中科院分区：
文献类型：
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作者：
Liang Song;Xianrui Xie;Cuiting Lv;Atta ur Rehman Khan;Yang Sun;Ruixue Li;Juan Yao;Mohamed EL-Newehy;Hany EL-Hamshary;Yosry Morsi;Xiumei Mo;Youcheng Yu
通过生物材料为基础的配方引导骨再生可以防止软组织通过屏障膜迁移到骨缺损区。然而，骨再生需要生物活性的外部干预。在这里，我们报道了一种可生物降解的电纺聚L乳酸/明胶基纳米纤维膜，包埋在表没食子儿茶素没食子酸酯(EGCG)的核心，具有光滑的轮廓，良好的物理化学性质，生物相容性，抗菌效果，足够的骨诱导能力，和EGCG的持续释放超过一周。70%的缺损区在EGCG负载的膜的帮助下修复，在8周内大约是对照组的1.5倍。综上所述，这些膜有望成为引导骨再生的候选材料。
Guided bone regeneration through biomaterial-based formulations can prevent soft tissue migration into the bone defect area through a barrier membrane. However, bone regeneration requires bioactive external interference. Here, we report a biodegradable electrospun poly-l-lactic acid/gelatin-based nanofibrous membrane encapsulating epigallocatechin gallate (EGCG) within the core, with a smooth profile, desirable physicochemical properties, biocompatibility, antibacterial effects, sufficient osteoinductive capability, and sustained EGCG release over one week. 70% of the defect area was repaired with the help of the EGCG-loaded membrane, approximately 1.5-fold improvement over the control group in 8 weeks. In conclusion, these membranes are promising candidates for guided bone regeneration.