Mechanisms linking osteoporosis with cardiovascular calcification.
Mechanisms linking osteoporosis with cardiovascular calcification.
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DOI：
10.1007/s11914-009-0008-1
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发表时间：
2009-07
影响因子：
4.3
通讯作者：
中科院分区：
文献类型：
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作者：
心血管钙沉积通过多种潜在机制与骨质疏松症相关，这些机制涉及纳米级分子调节因子，这些因子控制骨骼骨和心血管组织。在这篇综述中，讨论了心血管钙化和骨质疏松症之间的几种可能的机制，包括衰老、对慢性炎症的组织特异性反应、骨骼终动脉的血流限制性动脉粥样硬化导致代谢缺血异常、以相互方式影响两种组织的共享的内源性调节因素，以及半胱氨酸蛋白酶抑制剂胎球蛋白的变化。任何或所有这些因素和现象都可能促成这种关联。
Cardiovascular calcium deposition is associated with osteoporosis through a variety of potential mechanisms involving molecular regulatory factors at the nanoscale level that govern both skeletal bone and cardiovascular tissues. In this review, several possible mechanisms linking cardiovascular calcification and osteoporosis are discussed, including aging, tissue-specific responses to chronic inflammation, flow-limiting atherosclerosis of skeletal end-arteries causing ischemic abnormalities in metabolism, shared, endogenous regulatory factors that affect the two tissues in a reciprocal manner, and changes in a cysteine protease inhibitor, fetuin. Any or all of these factors and phenomena may contribute to the association.