Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes
Synthesis of a trimannosylated-equipped archaeal diether lipid for the development of novel glycoliposomes
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DOI：
10.1016/j.carres.2016.10.003
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发表时间：
2016-11-29
影响因子：
3.1
通讯作者：
Benvegnu, Thierry
中科院分区：
文献类型：
--
作者：
Barbeau, Julie;Lemiegre, Lok;Benvegnu, Thierry
设计并合成了一种古菌二醚脂质，其具有通过寡乙烯间隔基连接到(2S)-2-(植烷氧基)-3-(十六烷氧基)丙酸主链的α-D-吡喃甘露糖苷三天线(TriMan-Diether)。这种插入脂质体中的新甘露糖化脂质将分别由于 TriMan 结构和二醚尾部部分而表现出 DC 靶向和佐剂特性。 (C) 2016 Elsevier Ltd. 保留所有权利。
An archaeal diether lipid possessing a tri-antenna of alpha-D-mannopyranoside linked via an oligoethylene spacer to a (2S)-2-(phytanyloxy)-3-(hexadecyloxy)propanoic acid backbone (TriMan-Diether) was designed and synthesized. This new mannosylated lipid inserted in liposomes would show both DC-targeting and adjuvant properties thanks to the TriMan structure and the diether tail part, respectively. (C) 2016 Elsevier Ltd. All rights reserved.