maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer
maxPET: A dedicated mammary and axillary region PET imaging system for breast cancer
复制标题
DOI：
10.1109/23.940168
复制
发表时间：
2001-06-01
影响因子：
1.8
通讯作者：
Cherry, SR
中科院分区：
文献类型：
--
作者：
Doshi, NK;Silverman, RW;Cherry, SR
在本文中，我们介绍了专为乳腺和腋窝区域成像设计的高性能原型专用 PET 相机 (maxPET) 的初步测量结果。该系统由两个同时运行的 15 x 15 cm(2) 平面闪烁探测器板组成，每个板由 25 个模块化探测器组成。模块化探测器由 3 x 3 x 20 mm(3) 氧原硅酸镥 (LSO) 探测器元件组成的 9 x 9 阵列组成，由位置敏感光电倍增管 (PS-PMT) 读取。多路复用读出方案用于将读出通道数从每板 200 个（每个 PS-PMT 4X 和 4Y 读出）减少到 8 个通道。探测器测得的固有空间分辨率为 2.3 毫米。系统中超过 95% 的 4050 个晶体可以在检测器板的洪水直方图中识别出来。整个系统的重合定时分辨率为8.1 ns。使用系统扫描线源模型，并使用焦平面断层扫描重建图像。根据通过线源幻影图像获取的轮廓，投影图像的估计分辨率为 4 毫米。 maxPET 系统的目标是通过协助对具有致密纤维腺体乳房的女性进行成像、无需手术即可检测腋窝淋巴结转移以及监测化疗效果来帮助乳腺癌患者管理。 maxPET 系统的未来研究将集中于对电子设备的改变，以提高计数率性能和定时分辨率，以及将探测器安装在用于断层扫描研究的旋转机架上。
In this paper, we present initial measurements from a high-performance prototype dedicated PET camera (maxPET) designed for mammary and axillary region imaging. The system consists of two 15 x 15 cm(2) planar scintillation detector plates operating in coincidence, with each plate composed of 25 modular detectors. The modular detectors are comprised of a 9 x 9 array of 3 x 3 x 20 mm(3) lutetium oxyorthosilicate (LSO) detector elements, read out by a position-sensitive photomultiplier tube (PS-PMT). A multiplexing readout scheme is used to reduce the number of readout channels from 200 (4X and 4Y readouts per PS-PMT) to 8 channels per plate. The detectors have a measured intrinsic spatial resolution of 2.3 mm. Over 95% of the 4050 crystals in the system can be identified in flood histograms of the detector plates. The coincidence timing resolution for the entire system is 8.1 ns. A line source phantom was scanned with the system and images reconstructed using focal plane tomography. The estimated resolution in projection images is 4 mm based on profiles taken through the line source phantom images. The goal of the maxPET system will be to aid in breast cancer patient management by assisting in imaging women with dense fibro-glandular breasts, detecting axillary lymph node metastases without surgery, and monitoring chemotherapy effectiveness. Future research on the maxPET system will focus on changes to the electronics to improve count rate performance and timing resolution and the mounting of the detectors on a rotating gantry for tomographic studies.