Role of the Cell Cycle in Collective Cell Dynamics
Role of the Cell Cycle in Collective Cell Dynamics
复制标题
DOI：
10.1103/physrevx.11.031025
复制
发表时间：
2020-12
影响因子：
12.5
通讯作者：
Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto
中科院分区：
文献类型：
--
作者：
Jintao Li;S. Schnyder;M. S. Turner;R. Yamamoto
细胞以集落或组织形式共存。它们的行为受细胞间力和生化调节之间的相互作用控制。我们开发了一个简单的细胞周期模型，这是控制生长和分裂的基本调控网络，并将其与细胞集体内产生的物理力相结合。我们使用基于粒子的计算机模拟和连续理论来分析这个模型。我们专注于局限在通道中的2D菌落。这些细胞发展出分裂细胞的移动生长前沿，内部是静止细胞。这些前沿的轮廓和速度与基底摩擦和细胞周期参数有着密切的关系，这提供了一种在实验中测量这些参数的可能方法。
Cells coexist together in colonies or as tissues. Their behaviour is controlled by an interplay between intercellular forces and biochemical regulation. We develop a simple model of the cell cycle, the fundamental regulatory network controlling growth and division, and couple this to the physical forces arising within the cell collective. We analyse this model using both particle-based computer simulations and a continuum theory. We focus on 2D colonies confined in a channel. These develop moving growth fronts of dividing cells with quiescent cells in the interior. The profile and speed of these fronts are non-trivially related to the substrate friction and the cell cycle parameters, providing a possible approach to measure such parameters in experiments.