Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1α gene mutation carriers
Intrauterine hyperglycemia is associated with an earlier diagnosis of diabetes in HNF-1α gene mutation carriers
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DOI：
10.2337/diacare.25.12.2287
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发表时间：
2002-12-01
期刊：
影响因子：
16.2
通讯作者：
Hattersley, AT
中科院分区：
文献类型：
--
作者：
Stride, A;Shepherd, M;Hattersley, AT
Objective-in animals, experimentally induced maternal hyperglycemia during pregnancy results in hyperglycemic offspring. Similarly, Pima Indian offspring with mothers who are diabetic at the time of pregnancy have increased risk of early-onset diabetes. We hypothesized that exposure to hyperglycemia in utero would decrease the age at diagnosis of diabetes in patients with maturity-onset diabetes of the young (MODY) due to a mutation in the hepatocyte nuclear factor 1alpha (HNF-1alpha) gene.Research Design and Methods-We analyzed the affect of maternal diabetes on age at diagnosis of diabetes in 150 HNF-1alpha gene mutation carriers from 55 families.Results-Age at diagnosis in HNF-1alpha mutation carriers was younger when the mother was diagnosed before pregnancy compared With when the mother was diagnosed after pregnancy (15.5+/-5.4 vs. 27.5+/-13.1 years, P
