6 CASES OF WELL-DIFFERENTIATED ADENOCARCINOMA SIMULATING FETAL LUNG TUBULES IN PSEUDOGLANDULAR STAGE - COMPARISON WITH PULMONARY BLASTOMA
6 CASES OF WELL-DIFFERENTIATED ADENOCARCINOMA SIMULATING FETAL LUNG TUBULES IN PSEUDOGLANDULAR STAGE - COMPARISON WITH PULMONARY BLASTOMA
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DOI：
10.1097/00000478-198410000-00002
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发表时间：
1984-01-01
影响因子：
5.6
通讯作者：
SHIMASE, J
中科院分区：
文献类型：
--
作者：
KODAMA, T;SHIMOSATO, Y;SHIMASE, J
本文对6例类似胎儿肺的高分化腺癌进行了组织学、免疫组化和超微结构研究，并与3例肺母细胞瘤进行了比较。与肺母细胞瘤不同，6例均无肉瘤特征。单个肿瘤细胞特征性地具有透明的细胞质和丰富的糖原，并且类似于假腺期胎儿肺的分支小管的上皮细胞，以及肺母细胞瘤的上皮成分。它们也几乎不向粘液细胞和纤毛细胞分化。虽然在超微结构上没有发现含有内分泌型颗粒的细胞，但少数肿瘤细胞具有内分泌细胞的特征，即，胞浆内抗降钙素和抗胃泌素释放肽呈化学反应。因此，这种类型的腺癌被认为具有与肺母细胞瘤相似的组织发生，并且可能是仅显示上皮成分的肺母细胞瘤单侧发展的肿瘤。
Six cases [adult human] of well-differentiated adenocarcinoma resembling fetal lung were studied histologically, immunohistochemically, and ultrastructurally, and compared with 3 cases of pulmonary blastoma. The 6 cases had no sarcomatous features, unlike the pulmonary blastoma. Individual tumor cells characteristically possessed clear cytoplasm with plentiful glycogen and were similar to the epithelial cells of the branching tubules in the pseudoglandular stage of the fetal lung, as well as the epithelial component of pulmonary blastoma. They also showed little differentiation toward mucous cells and ciliated cells. Although cells containing endocrine-type granules were not found ultrastructurally, a few tumor cells possessed the characteristics of endocrine cells, i.e., cytoplasm was immunohistochemically reactive with anticalcitonin and antigastrin-releasing peptide. Therefore, this type of adenocarcinoma is considered to have a histogenesis similar to that of pulmonary blastoma and may be a tumor with 1-sided development of pulmonary blastoma showing only an epithelial component.