Light-regulated collective contractility in a multicellular choanoflagellate
Light-regulated collective contractility in a multicellular choanoflagellate
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DOI：
10.1126/science.aay2346
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发表时间：
2019-10-18
期刊：
影响因子：
56.9
通讯作者：
King, Nicole
中科院分区：
文献类型：
--
作者：
Brunet, Thibaut;Larson, Ben T.;King, Nicole
产生整体组织变形的集体细胞收缩是动物运动和形态发生的标志性特征。然而，动物集体收缩力的起源仍不清楚。在调查加勒比海库拉考岛的choanoflagellates，最近的生活亲属的动物，我们分离出一个以前未描述的物种（这里命名为Choanoeca flexa sp. nov.）形成多细胞杯状菌落。菌落迅速逆转其曲率，以响应不断变化的光线水平，他们通过视紫红质环磷酸鸟苷途径检测。倒置需要肌动球蛋白介导的顶端收缩，并允许进食和游泳行为之间的交替。C.因此，Flexa迅速地将感觉输入直接转化为多细胞收缩。这些发现可能为重建在专门的感觉和收缩细胞进化之前存在的假设动物祖先提供信息。
Collective cell contractions that generate global tissue deformations are a signature feature of animal movement and morphogenesis. However, the origin of collective contractility in animals remains unclear. While surveying the Caribbean island of Curacao for choanoflagellates, the closest living relatives of animals, we isolated a previously undescribed species (here named Choanoeca flexa sp. nov.) that forms multicellular cup-shaped colonies. The colonies rapidly invert their curvature in response to changing light levels, which they detect through a rhodopsin-cyclic guanosine monophosphate pathway. Inversion requires actomyosin-mediated apical contractility and allows alternation between feeding and swimming behavior. C. flexa thus rapidly converts sensory inputs directly into multicellular contractions. These findings may inform reconstructions of hypothesized animal ancestors that existed before the evolution of specialized sensory and contractile cells.