Network organization of the plant immune system: from pathogen perception to robust defense induction
Network organization of the plant immune system: from pathogen perception to robust defense induction
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DOI：
10.1111/tpj.15462
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发表时间：
2021-09-02
期刊：
影响因子：
7.2
通讯作者：
Roby, Dominique
中科院分区：
文献类型：
--
作者：
Delplace, Florent;Huard-Chauveau, Carine;Roby, Dominique
植物免疫系统主要是通过对定性抗性（一种简单的免疫形式）的研究，并从还原论的角度进行探索。最近对定量抗病基因的鉴定揭示了大量的功能，表明了更复杂的机制。此外，由于高通量分析和系统方法的出现，我们对免疫系统的看法变得更加综合，揭示了植物免疫应该被视为一个分布式和高度连接的分子网络，包括多种功能，以优化植物对病原体的防御表达。在这里，我们回顾了最近在了解导致植物免疫的调控通路的网络复杂性方面取得的进展，从病原体感知到信号通路，最后到免疫反应。我们还分析了这些网络的拓扑组织及其涌现特性，这对于预测新的免疫功能和实验测试至关重要。最后，我们报告了这些网络如何受到环境线索的调节。尽管系统方法在这一研究领域仍然非常缺乏，但越来越多的证据表明，植物对生物和非生物联合胁迫的反应不能从对单个胁迫的反应中推断出来。最后提出了在这个新生的生物学领域可能的研究途径的观点。
The plant immune system has been explored essentially through the study of qualitative resistance, a simple form of immunity, and from a reductionist point of view. The recent identification of genes conferring quantitative disease resistance revealed a large array of functions, suggesting more complex mechanisms. In addition, thanks to the advent of high-throughput analyses and system approaches, our view of the immune system has become more integrative, revealing that plant immunity should rather be seen as a distributed and highly connected molecular network including diverse functions to optimize expression of plant defenses to pathogens. Here, we review the recent progress made to understand the network complexity of regulatory pathways leading to plant immunity, from pathogen perception, through signaling pathways and finally to immune responses. We also analyze the topological organization of these networks and their emergent properties, crucial to predict novel immune functions and test them experimentally. Finally, we report how these networks might be regulated by environmental clues. Although system approaches remain extremely scarce in this area of research, a growing body of evidence indicates that the plant response to combined biotic and abiotic stresses cannot be inferred from responses to individual stresses. A view of possible research avenues in this nascent biology domain is finally proposed.