Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody.
Suppression of Abeta deposition in brain by peripheral administration of Fab fragments of anti-seed antibody.
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DOI：
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发表时间：
2005
影响因子：
3.1
通讯作者：
Naoki Yamamoto;T. Yokoseki;M. Shibata;H. Yamaguchi;K. Yanagisawa
中科院分区：
文献类型：
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作者：
Naoki Yamamoto;T. Yokoseki;M. Shibata;H. Yamaguchi;K. Yanagisawa
Assembly and deposition of amyloid beta-protein (Abeta) in the brain is a fundamental process of Alzheimer's disease (AD). We previously hypothesized that GM1 ganglioside-bound Abeta (GAbeta) is an endogenous seed for Abeta assembly in brain. Recently, we have succeeded in generation of a monoclonal antibody specific to GAbeta. Notably, this antibody, 4396C, per se substantially inhibits Abeta assembly in vitro. Here we report that the peripheral administration of Fab fragments of 4396C into transgenic mice expressing a mutant amyloid precursor protein gene, following the conjugation of the protein transduction domain of the Tat protein, markedly suppressed Abeta deposition in the brain. This result further supports our previous hypothesis and also provides a new insight into develop AD therapy through targeting seed Abeta in the brain, which selectively inhibits the initial step of the pathological process of AD.
