Well-Differentiated Villoglandular Adenocarcinoma of the Uterine Cervix: Assessment of Cytological Features by Histological Subtypes
Well-Differentiated Villoglandular Adenocarcinoma of the Uterine Cervix: Assessment of Cytological Features by Histological Subtypes
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DOI：
10.1159/000342917
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发表时间：
2013-01-01
期刊：
影响因子：
1.8
通讯作者：
Saito, Toshiaki
中科院分区：
文献类型：
--
作者：
Hagiwara, Tomoko;Kaku, Tsunehisa;Saito, Toshiaki
目的：宫颈高分化绒毛腺腺癌（VGA）累及乳头，乳头内衬不同类型的上皮细胞，组织学上分为宫颈内型、乳头状型和肠型。本研究的目的是评估明确的细胞学特征的VGA的组织学亚型。研究设计：我们检查了确诊为纯VGA患者的8份宫颈涂片，并将其分为3种组织学亚型。结果：宫颈涂片细胞密度高，背景相对干净。细胞核有极轻微的不等核和细颗粒染色质，核仁几乎不明显。颈管型的特征是栅栏状排列，由柱状或梭形细胞组成，细胞核顶端或细长。小而清晰的核仁仅在颈管型中发现。类圆形肿瘤细胞由边缘光滑的粘性片和非常圆的细胞核组成。胞质空泡化从未观察到类神经胶质瘤型。肠型肿瘤细胞突出，胞浆粘蛋白丰富。结论：我们证明了这种肿瘤的细胞学特征可以根据组织学亚型而变化，为了提高诊断的准确性，应该了解这些特征。版权所有（c）2012 S. Karger AG，巴塞尔
Objective: Well-differentiated villoglandular adenocarcinoma (VGA) of the cervix involves papillae lined by different types of epithelial cells that are histologically subclassified into endocervical, endometrioid, or intestinal subtypes. The objective of the current study was to evaluate the definite cytological features of VGA by histological subtype. Study Design: We examined 8 cervical smears from patients confirmed to have pure VGA and classified them into the 3 histological subtypes. Results: The cervical smears were highly cellular and had a relatively clean background. The nuclei had minimal anisonucleosis and fine granular chromatin with almost inconspicuous nucleoli. The characteristic findings of the endocervical type were a palisading arrangement consisting of columnar or spindle-shaped cells with apical or elongated nuclei. Small but clear nucleoli were identified only in the endocervical type. In the endometrioid type, tumor cells consisted of cohesive sheets with smooth edges and very round nuclei. Cytoplasmic vacuolation was never observed in the endometrioid type. The tumor cells in the intestinal type were prominent with abundant cytoplasmic mucin. Conclusions: We demonstrated that the cytological features of this tumor can vary depending on the histological subtype and one should be aware of these features in order to improve diagnostic accuracy. Copyright (c) 2012 S. Karger AG, Basel