Residence Near Power Lines and Mortality From Neurodegenerative Diseases: Longitudinal Study of the Swiss Population
Residence Near Power Lines and Mortality From Neurodegenerative Diseases: Longitudinal Study of the Swiss Population
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DOI：
10.1093/aje/kwn297
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发表时间：
2009-01-15
影响因子：
5
通讯作者：
Roeoesli, Martin
中科院分区：
文献类型：
--
作者：
Huss, Anke;Spoerri, Adrian;Roeoesli, Martin
对2000-2005年期间瑞士国家队列（将死亡率和人口普查数据联系起来）的470万人进行了住宅电力线磁场暴露与神经退行性疾病死亡率之间的关系分析。采用Cox比例风险模型分析了生活在220-380 kV电力线附近与神经退行性疾病死亡风险之间的关系，并对一系列潜在混杂因素进行了调整。总体而言，与居住在距离220-380千伏电力线50米以内的人相比，居住在距离600米或以上的人患阿尔茨海默病的调整风险比为1.24（95%可信区间（CI）： 0.80, 1.92）。在电力线附近居住年限与阿尔茨海默病之间存在剂量-反应关系：在50米范围内居住至少5年的人的调整风险比为1.51 (95% CI: 0.91, 2.51)，至少10年的人的调整风险比增加到1.78 (95% CI: 1.07, 2.96)，至少15年的人的调整风险比增加到2.00 （95% CI: 1.21, 3.33）。这种模式与老年痴呆症相似。几乎没有证据表明肌萎缩性侧索硬化症、帕金森病或多发性硬化症的风险增加。
The relation between residential magnetic field exposure from power lines and mortality from neurodegenerative conditions was analyzed among 4.7 million persons of the Swiss National Cohort (linking mortality and census data), covering the period 2000-2005. Cox proportional hazard models were used to analyze the relation of living in the proximity of 220-380 kV power lines and the risk of death from neurodegenerative diseases, with adjustment for a range of potential confounders. Overall, the adjusted hazard ratio for Alzheimer's disease in persons living within 50 m of a 220-380 kV power line was 1.24 (95% confidence interval (CI): 0.80, 1.92) compared with persons who lived at a distance of 600 m or more. There was a dose-response relation with respect to years of residence in the immediate vicinity of power lines and Alzheimer's disease: Persons living at least 5 years within 50 m had an adjusted hazard ratio of 1.51 (95% CI: 0.91, 2.51), increasing to 1.78 (95% CI: 1.07, 2.96) with at least 10 years and to 2.00 (95% CI: 1.21, 3.33) with at least 15 years. The pattern was similar for senile dementia. There was little evidence for an increased risk of amyotrophic lateral sclerosis, Parkinson's disease, or multiple sclerosis.