Neural correlates of disturbed perception of verticality
Neural correlates of disturbed perception of verticality
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DOI：
10.1212/wnl.0b013e318248e544
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发表时间：
2012-03-01
期刊：
影响因子：
9.9
通讯作者：
Dieterich, Marianne
中科院分区：
文献类型：
--
作者：
Baier, Bernhard;Suchan, Julia;Dieterich, Marianne
目的：皮质性卒中后垂直感会受到影响。然而，病变部位和病理感知垂直度之间的关系仍然是一个争论的问题，因为以前的研究显示矛盾的结果。因此，本研究的目的是测试特定的皮质病变是否与主观视觉垂直（SVV）的倾斜相关，并确定在病变的情况下引起这种倾斜的关键脑区。对54例患者的SVV进行了系统研究（22例左侧病变患者和32例右侧病变患者）急性单侧卒中，通过现代体素病变行为映射技术进行分析。这些数据提供了证据之间的关联SVV的倾斜和岛叶皮层（IC）和额下回（IFG）在两个半球。虽然IC似乎是左半球的突出结构，但IFG在右半球受到的影响最大。此外，其他皮质区域，如上级颞回（STG）和Rolandic岛盖以及皮质下枕额下束和上级纵束似乎参与了前庭-皮质网络，以感知滚动平面中的垂直度。这些区域的损伤可能会导致一个半球的前庭网络内的不平衡，由于多模态信号处理的缺陷。神经病学（R）2012;78：728-735
Objective: Perception of verticality can be perturbed after cortical stroke. However, a relationship between lesion location and pathologic perception of verticality is still a matter of debate since previous studies revealed contradictory results. Thus, the aim of the current study was to test whether specific cortical lesions were associated with tilts of subjective visual vertical (SVV) and to determine the critical brain areas that cause such tilts in the case of a lesion.Methods: SVV was systematically studied in 54 patients (22 patients with left-sided and 32 patients with right-sided lesions) with acute unilateral strokes, analyzed by modern voxel-wise lesion-behavior mapping techniques.Results: The data give evidence for an association between tilt of SVV and the insular cortex (IC) and inferior frontal gyrus (IFG) in both hemispheres. Whereas the IC seems to be the prominent structure in the left hemisphere, the IFG is most affected in the right hemisphere. Furthermore, other cortical regions such as the superior temporal gyrus (STG) and the rolandic operculum as well as-subcortically-the inferior occipitofrontal fascicle and the superior longitudinal fascicle seem to be involved in the vestibulo-cortical network for the perception of verticality in the roll plane.Conclusion: Damage to these regions might lead to an imbalance within the vestibular network of one hemisphere due to a deficit in multimodal signal processing. Neurology (R) 2012;78:728-735