Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels
Protective potential of Royal Jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels
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DOI：
10.1016/j.fct.2010.07.013
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发表时间：
2010-10-01
影响因子：
4.3
通讯作者：
Yilmaz, Fatma
中科院分区：
文献类型：
--
作者：
Cemek, Mustafa;Aymelek, Fatih;Yilmaz, Fatma
在土耳其民间医学中，蜂王浆(RJ)被用于治疗多种疾病。本研究描述了RJ对四氯化碳(CCl4)所致急性肝损伤的保护和抗氧化活性。本实验采用SD大鼠作为实验动物。CCl4(0.8毫升/公斤；S.C.)RJ(50、100、200 mg/kg：口服)隔日给药，连续20d。测定全血和组织中丙二醛、还原型谷胱甘肽：血清铜蓝蛋白、唾液酸、抗坏血酸、视黄醇、β-胡萝卜素和肝酶水平。此外，还检查了肝脏的组织病理学改变。RJ对CCl4所致的肝损伤和氧化应激均有明显的保护作用，从而减少脂质过氧化，改善内源性抗氧化防御系统。它还降低了升高的肝酶水平。组织病理学研究进一步证实了RJ的肝脏保护作用，与CCl4处理的对照组相比。综上所述，本研究揭示了使用RJ治疗化学性肝毒性的生物学证据。(C)2010爱思唯尔有限公司。保留所有权利。
Royal Jelly (RJ) is used in the Turkish folk medicine for the treatment of number of disorders. The present study describes the hepatoprotective and antioxidant activities of the RJ against carbon tetrachloride (CCl4)-induced acute liver damage. Sprague-Dawley rats were used for the experiment. CCl4 (0.8 ml/kg; s.c.) and RJ (50, 100, 200 mg/kg: orally) were given every other day, for 20 days. Malondialdehyde, reduced glutathione in whole blood and tissues: ceruloplasmin, sialic acid, ascorbic acid, retinol, beta-carotene and liver enzymes levels in serum were measured. Additionally, histopathological alterations in the liver were examined. RJ exerted the significant protective effect on liver damage as well as on oxidative stress induced by CCl4, resulting in reduced lipid peroxidation and improved endogenous antioxidant defence systems. It also reduced the elevated levels of liver enzymes. Histopathological study further confirmed the hepatoprotective effect of RJ, when compared with the CCl4 treated control groups. In conclusion, present study reveals biological evidence that supports the use of RJ in the treatment of chemical-induced hepatotoxicity. (C) 2010 Elsevier Ltd. All rights reserved.