Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy
Water-Soluble Nanoparticles with Twisted Double [7]Carbohelicene for Lysosome-Targeted Cancer Photodynamic Therapy
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具有扭曲双 [7]Carbohelicene 的水溶性纳米粒子用于溶酶体靶向癌症光动力疗法
DOI：
10.1002/smll.202105365
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Narita Akimitsu
中科院分区：
文献类型：
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作者：
Zhao Hao;Xu Xiushang;Zhou Long;Hu Yunbin;Huang Yiming;Narita Akimitsu
用于涉及I型和II型的细胞器靶向光动力学疗法（PDT）的基于螺烯的治疗剂具有挑战性，并且仍未充分探索。本文中，通过纳米沉淀法，通过与1，2-二硬脂酰基-sn-甘油基-3-磷酸乙醇胺-N-[甲氧基（聚乙二醇）-2000]的自组装制备含有扭曲双[7]碳螺烯（D 7 H-NP）的水溶性纳米颗粒。D 7 H-NP显示出高水溶性，平均尺寸为46 ± 2 nm。值得注意的是，D 7 H-NP在白色光照射下可以产生有效的单线态氧（1 O2）和超氧阴离子（O2· −），形成PDT的基础。此外，在4 T1癌细胞的溶酶体中的典型积累为使用D 7 H-NP用于溶酶体靶向癌症光疗法铺平了道路。本文报道了一种有前途的基于螺烯的光治疗剂，涉及I型和II型PDT用于细胞器靶向生物治疗。
Helicene‐based therapeutic agents for organelle‐targeted photodynamic therapy (PDT) involving both type I and II are challenging and still underexplored. Herein, water‐soluble nanoparticles containing twisted double [7]carbohelicene (D7H‐NPs) are prepared through self‐assembly with 1,2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐N‐[methoxy(polyethylene glycol)‐2000] by a nanoprecipitation method. D7H‐NPs display high water solubility with an average size of 46 ± 2 nm. Notably, D7H‐NPs can generate efficient singlet oxygen (1O2) and superoxide anion (O2· −) upon white light irradiation, forming the basis of PDT. Moreover, the typical accumulation in lysosomes of 4T1 cancer cells paves the way to use D7H‐NPs for lysosome‐targeted cancer phototherapeutics. This paper reports a promising helicene‐based phototherapeutic agent involving both type I and II PDT for organelle‐targeted biotherapy.