Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart
Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart
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DOI：
10.1098/rsta.2008.0311
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发表时间：
2009-06-13
期刊：
影响因子：
5
通讯作者：
Smith, Nicolas
中科院分区：
文献类型：
--
作者：
Lee, Jack;Niederer, Steven;Smith, Nicolas
本文综述了多物理场、多尺度耦合技术在全心脏生理模型构建中的发展和应用。通过检查最近的计算建模的发展，我们分析耦合机制的意义，增加了解心脏功能的兴奋收缩，冠状动脉血流和心室流体机械耦合的领域。在这些生理领域内，我们展示和讨论模型参数化，基于成像的模型解剖和计算实现的重要性。
In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss the importance of model parametrization, imaging-based model anatomy and computational implementation.