Ferrofluids of magnetic multicore nanoparticles for biomedical applications
Ferrofluids of magnetic multicore nanoparticles for biomedical applications
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DOI：
10.1016/j.jmmm.2009.02.073
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发表时间：
2009-05-01
影响因子：
2.7
通讯作者：
Zeisberger, Matthias
中科院分区：
文献类型：
--
作者：
Dutz, Silvio;Clement, Joachim H.;Zeisberger, Matthias
对于各种基于磁性的生物医学应用，使用相对较大（d > 420 nm）磁性核壳纳米颗粒的沉降稳定悬浮液是有利的。用羧甲基右旋糖酐壳包覆多核纳米颗粒的水基悬浮液（通过改进的碱沉淀法合成）。所得到的铁磁流体具有结构和磁性特征。结果表明，这些流体的比热功率约为60W/g （f = 400 kHz, H = 10kA/m）。通过基于离心的简单分馏方法，该值增加到330W/g。最后，证明了多核纳米颗粒的细胞摄取。(c) 2009 Elsevier B.V.版权所有
For a variety of magnetically based biomedical applications, it is advantageous to use sedimentation stable suspensions of relatively large(d > 420 nm) magnetic core-shell nanoparticles. Water-based suspensions of multicore nanoparticles were prepared by coating of the particles (synthesized by means of a modified alkaline precipitation method) with a carboxymethyldextran shell. The resulting ferrofluids were structurally and magnetically characterized. It was found that these fluids show a specific heating power of about 60W/g (f = 400 kHz, H = 10kA/m). This value was increased upto 330W/g by a simple fractionation method based on centrifugation. Finally, the cellular uptake of the multicore nanoparticles was demonstrated. (c) 2009 Elsevier B.V. All rights reserved.