Stroke risk predicts verbal fluency decline in healthy older men: Evidence from the normative aging study
Stroke risk predicts verbal fluency decline in healthy older men: Evidence from the normative aging study
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DOI：
10.1093/geronb/56.6.p340
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发表时间：
2001-11-01
影响因子：
6.2
通讯作者：
Gaziano, JM
中科院分区：
文献类型：
--
作者：
Brady, CB;Spiro, A;Gaziano, JM
中风的危险因素导致大脑白色物质的缺血性变化，这可能比其他大脑功能更影响额叶功能。因此，中风风险可能会特别影响传统上与额叶功能相关的行为指标，如语言流畅性。作者在235名健康老年男性（平均年龄= 66.41岁）中检查了这一假设，这些男性同时接受了两次医学和神经心理学检查，间隔3年。中风风险与语言流畅性、记忆力和视觉空间表现下降之间的关系通过回归分析，控制年龄和教育。年龄与所有认知功能的下降相关;中风风险仅与语言流畅性的下降相关。中风风险与流畅性下降之间的关系是年龄与流畅性下降之间关系的80%。这些结果表明，中风的风险竞争对手的影响，年龄对语言流畅性的表现。
Risk factors for stroke cause ischemic changes in the cerebral white matter that may affect frontal lobe functions more than other brain functions. Therefore, stroke risk could specifically affect performance on behavioral indexes traditionally associated with frontal lobe function such as verbal fluency. The authors examined this hypothesis in 235 healthy older men (mean age = 66.41 years) who received concurrent medical and neuropsychological examinations twice at a 3-year interval. Relations between stroke risk and decline in verbal fluency, memory, and visuospatial performance were analyzed through regression, controlling for age and education. Age was associated with decline in all cognitive functions; stroke risk was associated with decline only on verbal fluency. The relation between stroke risk and fluency decline was 80% as large as that between age and fluency decline. These results suggest that stroke risk rivals the effects of aging on verbal fluency performance.