Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings
Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings
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DOI：
10.1097/qad.0b013e32832d84fd
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发表时间：
2009-09-10
期刊：
影响因子：
3.8
通讯作者：
van Rooyen, Heidi
中科院分区：
文献类型：
--
作者：
Rollins, Nigel;Mzolo, Similo;van Rooyen, Heidi
目的：了解免疫门诊6周龄婴儿HIV检测的可接受性和可行性，以实现HIV的早期诊断和HIV治疗护理服务的转诊。设计：观察性队列干预。方法：在夸祖鲁纳塔尔邦3家诊所为所有带婴儿接种的母亲提供常规婴儿HIV检测。在滤纸上用脚后跟穿刺法采集血样。干血点被检测HIV抗体，如果有的话，用聚合酶链式反应检测HIV DNA。结果：在646名带婴儿进行免疫接种的母亲中，584名(90.4%)同意对其婴儿进行HIV检测，332名(56.8%)随后返回接受结果。在646名母亲和婴儿中，有332人(51.4%)在婴儿3个月大时确认或确认了他们的艾滋病毒状况。总体而言，在584份婴儿干血点样本中，有247份(42.3%)具有表明母亲艾滋病毒状况的艾滋病毒抗体。其中54例(21.9%)标本经聚合酶链式反应检测为HIV-DNA阳性。这相当于所有接受测试的婴儿的9.2%(54/584)。大多数受访母亲表示，她们对在免疫诊所对婴儿进行检测感到满意，并将推荐给其他人。结论：在免疫诊所对所有婴儿进行筛查是可以接受的，是可行的，可以作为早期识别HIV感染婴儿和转介进行抗逆转录病毒治疗的手段。(C)2009年Wolters Kluwer Health|Lippincott Williams&Wilkins
Objective: To determine the acceptability and feasibility of universal HIV testing of 6-week-old infants attending immunization clinics to achieve early diagnosis of HIV and referral for HIV treatment and care services.Design: An observational cohort with intervention.Methods: Routine HIV testing of infants was offered to all mothers bringing infants for immunizations at three clinics in KwaZulu Natal. Blood samples were collected by heel prick onto filter paper. Dried blood spots were tested for HIV antibodies and, if present, were tested for HIV DNA by PCR. Exit interviews were requested of all mothers irrespective of whether they had agreed to infant testing or not.Results: Of 646 mothers bringing infants for immunizations, 584 (90.4%) agreed to HIV testing of their infant and 332 (56.8%) subsequently returned for results. Three hundred and thirty-two of 646 (51.4%,) mothers and infants thereby had their HIV status confirmed or reaffirmed by the time the infant was 3 months of age. Overall, 247 of 584 (42.3%) infant dried blood spot samples had HIV antibodies indicating maternal HIV status. Of these, 54 (21.9%) samples were positive for HIV DNA by PCR. This equates to 9.2% (54/584) of all infants tested. The majority of mothers interviewed said they were comfortable with testing of their infant at immunization clinics and would recommend it to others.Conclusion: Screening of all infants at immunization clinics is acceptable and feasible as a means for early identification of HIV-infected infants and referral for antiretroviral therapy. (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins