Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts.
Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts.
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DOI：
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发表时间：
1997
影响因子：
13
通讯作者：
Gary R. Grotendorst
中科院分区：
文献类型：
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作者：
Gary R. Grotendorst
结缔组织生长因子 (CTGF) 是一种富含半胱氨酸的促有丝分裂肽，可与肝素结合，并在用转化生长因子 β (TGF-β) 激活后由成纤维细胞分泌。 CTGF 是高度保守的肽家族的成员，该家族包括立即早期基因产物 cef10、cyr61、fisp12；假定的禽类原癌基因，11月；果蝇基因，扭曲原肠胚形成，tsg，在背腹轴模式形成过程中控制内侧中胚层诱导，该过程也由 TGF-β 相关肽（dpp，scw）控制。在成年哺乳动物中，CTGF 作为 TGF-β 对结缔组织细胞作用的下游介质，刺激细胞增殖和细胞外基质合成。 CTGF 似乎不作用于上皮细胞或免疫细胞。由于 TGF-β 的生物学作用很复杂，并且影响许多不同的细胞类型，因此 CTGF 可以作为选择性干预伤口修复或纤维化疾病期间涉及结缔组织形成的过程的更具体的靶标。 Northern 印迹和原位杂交研究表明，在迄今为止检查的每种纤维化疾病中，CTGF 与 TGF-β 协调表达。抑制 CTGF 产生或作用的药物可能会导致控制人类纤维化疾病的新治疗方法的开发。
Connective tissue growth factor (CTGF) is a cysteine-rich mitogenic peptide that binds heparin and is secreted by fibroblasts after activation with transforming growth factor beta (TGF-beta). CTGF is a member of a highly conserved family of peptides that include immediate early gene products cef10, cyr61, fisp12; a putative avian proto-oncogene, nov; and a drosophila gene, twisted gastrulation, tsg, that controls medial mesoderm induction during dorsal-ventral axis pattern formation, a process also controlled by TGF-beta related peptides (dpp, scw). In the adult mammal, CTGF functions as a downstream mediator of TGF-beta action on connective tissue cells, where it stimulates cell proliferation and extracellular matrix synthesis. CTGF does not appear to act on epithelial cells or immune cells. Because the biological actions of TGF-beta are complex and affect many different cell types, CTGF may serve as a more specific target for selective intervention in processes involving connective tissue formation during wound repair or fibrotic disorders. Northern blot and in situ hybridization studies have demonstrated that CTGF is coordinately expressed with TGF-beta in every fibrotic disorder examined to date. Agents that inhibit CTGF production or action could lead to the development of new therapeutic approaches for the control of fibrotic disorders in humans.