Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumors
Allelic loss at 1p and 19q frequently occurs in association and may represent early oncogenic events in oligodendroglial tumors
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1p 和 19q 等位基因缺失经常联合发生，可能代表少突胶质细胞肿瘤的早期致癌事件
DOI：
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发表时间：
1995
影响因子：
6.4
通讯作者：
J. Rey
中科院分区：
文献类型：
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作者：
M. Bello;P. Leone;J. Vaquero;J. M. Campos;M. Kusak;J. Sarasa;A. Pestaña;J. Rey
少突胶质细胞肿瘤的发生和发展的分子机制知之甚少，因为只有有限的信息从孤立的情况下杂合性丢失。最常见的改变似乎涉及1p和19q的缺失，而在单个肿瘤中描述了9p、10号染色体或表皮生长因子受体基因扩增的杂合性丢失。我们已经应用限制性片段长度多态性分析，以确定这些抑制基因的参与肿瘤的发生，在一系列的25个肿瘤与少突胶质细胞的成分，覆盖染色体1和染色体19上的7个位点的14个位点。25个样本中的22个和19个分别在1p和19 q处显示洛缺失，在17个样本中检测到两种异常相关，包括低级别和高级别少突胶质细胞瘤以及混合型少突星形细胞瘤。我们的研究结果表明，位于1 p和19 q上的肿瘤抑制基因的失活代表了少突胶质细胞肿瘤致癌转化早期阶段发生的协同改变。© 1995 Wiley利斯公司
The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromosome 10 or epidermal growth factor receptor gene amplification have been described in single tumors. We have applied restriction fragment length polymorphism analysis to 14 loci covering chromosome 1 and 7 loci on chromosome 19 in a series of 25 tumors with an oligodendroglial component to determine precisely the participation of these suppressor genes in the genesis of tumors. Twenty‐two and 19 of the 25 samples displayed LOH at 1p and 19q, respectively, and both anomalies were detected in association in 17 samples, including low‐ and high‐grade oligodendrogliomas as well as mixed oligo‐astrocytomas. Our findings suggest that inactivation of tumor suppressor genes located on 1p and 19q represent cooperative alterations occurring at early stages of oncogenic transformation of oligodendroglial neoplasms. © 1995 Wiley‐Liss, Inc.
非星形细胞人脑肿瘤中的 p53 突变。
影响因子：
11.2
作者：
Ohgaki,H;Eibl,RH;Wiestler,OD;Yasargil,MG;Newcomb,EW;Kleihues,P
通讯作者：
Kleihues,P
低度中枢神经系统肿瘤的染色体异常。
影响因子：
--
作者：
Griffin,CA;Long,PP;Carson,BS;Brem,H
通讯作者：
Brem,H